Evidence map›Paper›PMID 39240093›Full record

ArticleAntimicrobial agents and chemotherapy2024

Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice.

Aaron F Carlin, James R Beadle, Jeremy Ardanuy, Alex E Clark, Victoria Rhodes, Aaron F Garretson, Joyce A Murphy, Nadejda Valiaeva, Robert T Schooley, Matthew B Frieman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Oral lipid prodrug V2043 (1-Antimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aaron F CarlinDepartment of Pathology, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-1669-8066
James R BeadleDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Jeremy ArdanuyDepartment of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, USA.
Alex E ClarkDepartment of Pathology, University of California San Diego, La Jolla, California, USA.
Victoria RhodesDepartment of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, USA.
Aaron F GarretsonDepartment of Pathology, University of California San Diego, La Jolla, California, USA.
Joyce A MurphyDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Nadejda ValiaevaDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Robert T SchooleyDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Matthew B FriemanDepartment of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-0107-0775
Karl Y HostetlerDepartment of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-1155-2885

Funding

Development of Sustained-Release Anti-HIV Nucleoside Phosphonate NanoparticlesR01AI131424 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHOOLEY, ROBERT TURNER · 2017 to 2021
$3.8M
Revising Anti-coronavirus Compounds to Enhance Activity and Optimize DeliveryR01AI161348 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karl Y Hostetler, Robert Turner Schooley · 2021 to 2026
$3.1M
Burroughs Wellcome Fund (BWF) Career Award for Medical ScientistsNIAID NIH HHS R01 AI131424NIAID NIH HHS R01 AI161348UC | UCSD | Center for AIDS Research, University of California, San Diego (CFAR)
6 · The paper itself

Abstract

Oral broad-spectrum antivirals are urgently needed for the treatment of many emerging and contemporary RNA viruses. We previously synthesized 1-

Indexed as

Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19 Drug TreatmentProdrugsSARS-CoV-2AdenosineAdministration, OralAnimalsChlorocebus aethiopsCOVID-19Disease Models, AnimalFemaleHumansLungMiceAdenosineAdenosine MonophosphateAlanineAntiviral AgentsGS-441524PhospholipidsProdrugsremdesivirantiviral agentbroad spectrum antiviralCOVID-19in vivo efficacylipid prodrugmouse modelpharmacokineticsremdesivirremdesivir nucleosideSARS-CoV-2

Identifiers

PMID39240093
PMCPMC11459966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.