Evidence map›Paper›PMID 39240055›Full record

ArticleAdvanced healthcare materials2025

Extracellular Vesicles Delivered by a Nanofiber-Hydrogel Composite Enhance Healing In Vivo in a Model of Crohn's Disease Perianal Fistula.

Ling Li, Zhicheng Yao, Kevan J Salimian, Jiayuan Kong, Atif Zaheer, Alyssa Parian, Susan L Gearhart, Hai-Quan Mao, Florin M Selaru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling LiDivision of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4498-9466
Zhicheng YaoInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
Kevan J SalimianDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jiayuan KongInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
Atif ZaheerDepartment of Radiology & Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Alyssa ParianDivision of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Susan L GearhartDivision of Colorectal Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hai-Quan MaoInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
Florin M SelaruDivision of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-7990-8238

Funding

A nanofiber-hydrogel composite plug for perianal fistula repairR01DK135269 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Hai-Quan Mao, Florin Selaru · 2023 to 2026
$2.6M
NIDDK NIH HHS G-2019PG-CD025NIDDK NIH HHS R01 DK135269
6 · The paper itself

Abstract

Perianal fistulas represent a common, aggressive, and disabling complication of Crohn's disease (CD). Despite recent drug developments, novel surgical interventions as well as multidisciplinary treatment approaches, the outcome is dismal, with >50% therapy failure rates. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) offer potential therapeutic benefits for treating fistulizing CD, due to the pro-regenerative paracrine signals. However, a significant obstacle to clinical translation of EV-based therapy is the rapid clearance and short half-life of EVs in vivo. Here, an injectable, biodegradable nanofiber-hydrogel composite (NHC) microgel matrix that serves as a carrier to deliver MSC-derived EVs to a rat model of CD perianal fistula (PAF) is reported. It is found that EV-loaded NHC (EV-NHC) yields the best fistula healing when compared to other treatment arms. The MRI assessment reveals that the EV-NHC reduces inflammation at the fistula site and promotes tissue healing. The enhanced therapeutic outcomes are contributed by extended local retention and sustained release of EVs by NHC. In addition, the EV-NHC effectively reduces inflammation at the fistula site and promotes tissue healing and regeneration via macrophage polarization and neo-vascularization. This EV-NHC platform provides an off-the-shelf solution that facilitates its clinical translation.

Indexed as

Crohn DiseaseExtracellular VesiclesHydrogelsNanofibersRectal FistulaWound HealingAnimalsDisease Models, AnimalHumansMaleMesenchymal Stem CellsRatsRats, Sprague-DawleyHydrogelsCrohn's diseaseextracellular vesiclesnanofiber‐hydrogel compositesperianal fistulatherapy

Identifiers

PMID39240055
PMCPMC11882933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.