Evidence map›Paper›PMID 39240048›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.

Anna M VandeBunte, Hyunwoo Lee, Emily W Paolillo, Ging-Yuek Robin Hsiung, Adam M Staffaroni, Rowan Saloner, Carmela Tartaglia, Kristine Yaffe, David S Knopman, Eliana Marisa Ramos and 25 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Anna M VandeBunteDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.ORCID 0000-0002-5167-3358
Hyunwoo LeeDivision of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Emily W PaolilloDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Ging-Yuek Robin HsiungDivision of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Adam M StaffaroniDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Rowan SalonerDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kristine YaffeDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Eliana Marisa RamosDavid Geffen School of Medicine at UCLA, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, USA.
Katya RascovskyDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrea C BozokiDepartment of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
Bonnie WongHarvard Massachusetts General Hospital Frontotemporal Disorders Unit, Charlestown, Massachusetts, USA.
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington, Seattle, Washington, USA.
Allison SnyderNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Peter PressmanDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Mario F MendezDavid Geffen School of Medicine at UCLA, Reed Neurological Research Center, Los Angeles, California, USA.
Irene LitvanSan Diego Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Julie A FieldsDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Douglas R GalaskoSan Diego Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Ryan DarbyDepartment of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
Joseph C MasdeuHouston Methodist Neurological Institute, Houston, Texas, USA.
Maria Belen PasqualHouston Methodist Neurological Institute, Houston, Texas, USA.
Lawrence S HonigDepartment of Neurology, Irving Medical Center, Columbia University, New York, New York, USA.
Nupur GhoshalDepartment of Neurology, St. Louis School of Medicine, Washington University, St. Louis, Missouri, USA.
Brian S ApplebyDepartment of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
Ian R MackenzieDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Hilary W HeuerDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Joel H KramerDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Adam L BoxerDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Brad BoeveDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Howard J RosenDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Kaitlin B CasalettoDepartment of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
ALLFTD Consortium

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$120.9M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Leveraging mouse and human models to investigate neuroprotective effects of blood-derived exerkines in Alzheimer's diseaseR56AG082414 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B, VILLEDA, SAUL A · 2023 to 2023
$1.2M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
Advancing Research and Treatment in Frontotemporal Lobar Degeneration U54NS092089ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration K23AG058752ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration P01AG019724ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration R01AG072475ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration R56AG082414ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration U19AG063911ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration U24 AG21886Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects U01AG045390NIANIA NIH HHS K23 AG058752NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG072475NIA NIH HHS R56 AG082414NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIHNINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

introductionCardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life's Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).

methodsTwo hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.

resultsAmong variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories. DISCUSSION: Better baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD. HIGHLIGHTS: Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.

Indexed as

Disease ProgressionFrontotemporal Lobar DegenerationNeuropsychological TestsAgedBrainCognitive DysfunctionFemaleHeterozygoteHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingWhite Matteragingcardiovascular healthfrontotemporal dementiagenetic dementiaLife's Simple 7lifestyle behaviorsmodifiable riskneuropsychology

Identifiers

PMID39240048
PMCPMC11485313

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.