Evidence map›Paper›PMID 39240040›Full record

Trial reportEuropean journal of heart failure2024

Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX-AHF-2 trial.

Riccardo M Inciardi, Laura Staal, Beth Davison, Carlo M Lombardi, Douwe Postmus, Michael G Felker, Gerasimos Filippatos, Barry Greenberg, Peter S Pang, Piotr Ponikowski and 6 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Riccardo M InciardiCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Laura StaalDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Beth DavisonMomentum Research and Inserm U942 MASCOT, Paris, France.
Carlo M LombardiCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Douwe PostmusDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Michael G FelkerDuke University School of Medicine and Duke Clinical Research Institute, Durham, NC, USA.
Gerasimos FilippatosDepartment of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Barry GreenbergSulpizio Family Cardiovascular Center, University of California San Diego Health, La Jolla, CA, USA.
Peter S PangDepartment of Emergency Medicine, Indiana University, Indianapolis, IN, USA.
Piotr PonikowskiDepartment of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
Thomas SeverinNovartis Pharma, Basel, Switzerland.
Claudio GimpelewiczNovartis Pharma, Basel, Switzerland.
John TeerlinkSection of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Gad CotterMomentum Research and Inserm U942 MASCOT, Paris, France.
Adriaan A VoorsDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Marco MetraCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAcute heart failure (AHF) is a major cause of hospitalizations and death in the elderly. However, elderly patients are often underrepresented in randomized clinical trials. We analysed the impact of age on clinical outcomes and response to treatment in patients enrolled in Relaxin in Acute Heart Failure (RELAX-AHF-2), a study that included older patients than in previous AHF trials. METHODS AND

resultsThe RELAX-AHF-2 randomized patients admitted for AHF to infusion of serelaxin or placebo. We examined the association of pre-specified clinical outcomes and treatment effect according to age categories [(years): <65 (n = 1411), 65-74 (n = 1832), 75-79 (n = 1222), 80-84 (n = 1156) and ≥85 (n = 924)]. The mean age of the 6545 patients enrolled in RELAX-AHF-2 was 73.0 ± 11 years. The risk of all-cause and cardiovascular (CV) death (all p < 0.001) as well as the composite endpoint of CV death or heart failure/renal failure rehospitalization through 180 days (p = 0.002) and hospital discharge through day 60 (p = 0.013) were all directly associated with age categories. Age remained independently associated with outcomes after adjustment for clinical confounders and the results were consistent when age was analysed continuously. No clinically significant change in treatment effects of serelaxin was observed across age categories for the pre-specified endpoints (interaction p > 0.05).

conclusionElderly patients are at higher risk of short- and long-term CV outcomes after a hospitalization for AHF. Further efforts are needed to improve CV outcomes in this population.

Indexed as

Heart FailureRecombinant ProteinsRelaxinAcute DiseaseAgedAged, 80 and overAge FactorsDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeRecombinant ProteinsRelaxinserelaxin protein, humanAcute heart failureAgeComorbiditiesSerelaxin

Identifiers

PMID39240040
PMCPMC11659486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.