Evidence map›Paper›PMID 39239914›Full record

ArticleVirulence2024

Human tetraspanin CD81 facilitates invasion of

Kris Gerard Alvarez, Lisa Goral, Abdulhadi Suwandi, Lisa Lasswitz, Francisco J Zapatero-Belinchón, Katrin Ehrhardt, Kumar Nagarathinam, Katrin Künnemann, Thomas Krey, Agnes Wiedemann and 2 more

Abstract read
In one paragraph

Article in Virulence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kris Gerard AlvarezInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.
Lisa GoralInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.
Abdulhadi SuwandiInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.
Lisa LasswitzDepartment of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), Tierärztliche Hochschule Hannover, Hannover, Germany.
Francisco J Zapatero-BelinchónDepartment of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), Tierärztliche Hochschule Hannover, Hannover, Germany.
Katrin EhrhardtInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.
Kumar NagarathinamInstitute for Biochemistry, Universität zu Lübeck, Lübeck, Germany.
Katrin KünnemannInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.
Thomas KreyInstitute for Biochemistry, Universität zu Lübeck, Lübeck, Germany.
Agnes WiedemannIRSD - Institut de Recherche en Santé Digestive, ENVT, INRAE, INSERM, Université́ de Toulouse, UPS, Toulouse, France.
Gisa GeroldDepartment of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), Tierärztliche Hochschule Hannover, Hannover, Germany.
Guntram A GrasslInstitute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Germany.ORCID 0000-0003-3718-2090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular loop domains. Tetraspanins are known as molecular facilitators, which assemble and organize cell surface receptors and partner molecules forming clusters known as tetraspanin-enriched microdomains. They have been implicated to play various biological roles including an involvement in infections with microbial pathogens. Here, we demonstrate an important role of CD81 for the invasion of epithelial cells by

Indexed as

Epithelial CellsSalmonella entericaTetraspanin 28Tetraspanin 29AnimalsHep G2 CellsHT29 CellsHumansRatsSalmonella InfectionsSalmonella typhimuriumCD81 protein, humanCD9 protein, humanTetraspanin 28Tetraspanin 29infectionintestinal epitheliuminvasionSalmonellatetraspanins

Identifiers

PMID39239914
PMCPMC11423668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.