Evidence map›Paper›PMID 39239784›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Initial Experience of Metabolic Imaging With Hyperpolarized [1-

Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Zoltan Laszik, Peder E Z Larson, Zhen J Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xiaoxi LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-0657-8922
Ying-Chieh LaiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Di CuiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-7069-339X
Shiang-Cheng KungDepartment of Medicine, University of California San Francisco Medical Center, San Francisco, California, USA.
Meyeon ParkDepartment of Medicine, University of California San Francisco Medical Center, San Francisco, California, USA.
Zoltan LaszikDepartment of Pathology, University of California San Francisco Medical Center, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Funding

Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor AggressivenessR01CA249909 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2025
$3.2M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
Hyperpolarized 13C Metabolic MRI for Noninvasive Monitoring of Kidney InjuryR21DK130002 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2022
$444k
National Institute of Health P41EB013598National Institute of Health R01CA249909National Institute of Health R21DK130002National Institute of Health S10OD025077NCI NIH HHS R01 CA249909NIDDK NIH HHS R21 DK130002
6 · The paper itself

Abstract

backgroundKidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage. PURPOSE: To investigate the feasibility of hyperpolarized (HP) [1- STUDY TYPE: Prospective. SUBJECTS: Six participants (mean age, 45.2 ± 12.4 years, two females) scheduled for kidney allograft biopsy and five patients (mean age, 59.6 ± 10.4 years, two females) with renal cell carcinoma (RCC). FIELD STRENGTH/SEQUENCE: Three Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP ASSESSMENT: Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1- STATISTICAL TESTS: Descriptive statistics (mean ± SD).

resultsBiopsy was performed a mean of 9 days (range 5-19 days) after HP [1- DATA

conclusionStable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.

Indexed as

KidneyKidney TransplantationMagnetic Resonance ImagingPyruvic AcidAdultAllograftsBiopsyCarbon IsotopesCarcinoma, Renal CellFeasibility StudiesFemaleGlomerular Filtration RateHumansKidney NeoplasmsMaleMiddle AgedCarbon-13Carbon IsotopesPyruvic Acid[1‐13C]lactate[1‐13C]pyruvatehyperpolarized 13Ckidney transplant

Identifiers

PMID39239784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.