ArticleInterventional pain medicine2024
Pain in osteoarthritis: Driven by intrinsic rather than extrinsic joint afferents and why this should impact treatment.
Article in Interventional pain medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mid- to long-term outcomes of medial opening wedge supramalleolar osteotomy for varus ankle osteoarthritis: a minimum seven-year follow-up study.International orthopaedics · 2026Article
- 3D Light sheet microscopy reveals aging osteoarthritis-associated joint-innervated nerve remodeling in mouse knee joints.Osteoarthritis and cartilage · 2026Article
- Three-dimensional visualization of nerves in bones of the human hand in osteoarthritis.JBMR plus · 2026Article
- Superolateral Genicular Nerve Block Added to Medial Blocks in Medial Knee Osteoarthritis.Journal of pain research · 2026Article
- Targeting the intrinsic bone nerve supply for joint denervation in osteoarthritis: A Copernican revolution, or just another fad relegated to the graveyard of scientific history?Interventional pain medicine · 2025Article
- Distribution of epiphyseal nutrient foramina in the distal femur: Implications for anterior knee joint denervation.Interventional pain medicine · 2025Article
- Non-surgical interventional treatments for knee osteoarthritis: The need for different perspectives, cross-specialty collaboration, and preclinical and translational research.Interventional pain medicine · 2024Article
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Authors and funding
1 author.
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Abstract
Pain in osteoarthritis (OA) results from erosion of joint cartilage, resulting in bone contacting bone without an intervening cushion. The periosteum, including its nociceptive innervation, ends at the border of the cartilage. No other innervated tissue is present between the denuded articular bone ends that could serve as a neuronal pathway to carry a bone-on-bone pain signal to the brain. The pain signaling pathway must therefore originate in afferent axons with electrogenic nociceptive sensory endings that reside within the bone itself, specifically in the opposing surfaces of epiphyseal subchondral bone. Selective ablation of this intrinsic nerve pathway, using any of a variety of approaches, is expected to permanently eliminate OA pain.
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