Evidence map›Paper›PMID 39238853›Full record

ArticleJACC. Advances2024

Blood Pressure and Cardiovascular Risk in Women With Breast Cancer: The Pathways Heart Study.

Douglas J Leedy, Jay M Voit, Eileen Rillamas-Sun, Marilyn L Kwan, Hanjie Shen, Song Li, Cecile A Laurent, Jamal S Rana, Valerie S Lee, Janise M Roh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Douglas J LeedyDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
Jay M VoitDivision of Cardiology, VA Puget Sound Health Care System, Seattle, Washington, USA.
Eileen Rillamas-SunDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Marilyn L KwanDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Hanjie ShenDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Song LiDivision of Cardiology, Medical City Healthcare, Dallas, Texas, USA.
Cecile A LaurentDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Jamal S RanaDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Valerie S LeeDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Janise M RohDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Yuhan HuangDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Heather GreenleeDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Richard K ChengDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.

Funding

Infrastructure for Pathways, a Prospective Study of Breast Cancer SurvivorshipU01CA195565 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI AMBROSONE, CHRISTINE B., KUSHI, LAWRENCE H · 2016 to 2025
$18.8M
Developing CVD prediction models for women with early stage breast cancerU01CA214057 · NCI · FRED HUTCHINSON CANCER CENTER · PI Heather Greenlee · 2025 to 2026
$1.5M
NCI NIH HHS U01 CA195565NCI NIH HHS U01 CA214057
6 · The paper itself

Abstract

Background: Hypertension is an important contributor to cardiovascular disease (CVD) in breast cancer (BC) survivors; however, research on blood pressure (BP) and CVD outcomes in BC survivors is limited. Objectives: The purpose of this study was to better characterize the association between BP and CVD in a large, longitudinal cohort of BC patients. Methods: Women with invasive BC diagnosed from 2005 to 2013 at Kaiser Permanente Northern California were matched 1:5 to women without BC. Patient data were obtained from electronic health records. Multivariable Cox regression and penalized spline models were used to explore the linear and nonlinear relationship of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on CVD outcomes. Results: BC cases (n = 12,713) and controls (n = 55,886) had median follow-up of 9.6 years (IQR: 5.0-11.9 years). Women with BC had a mean age of 60.6 years; 64.8% were non-Hispanic White. For ischemic heart disease (IHD), every 10 mmHg increase in SBP and DBP was associated with 1.23 (95% CI: 1.14-1.33) and 1.10 (95% CI: 0.98-1.24) risk, respectively, in women with BC. For stroke, every 10 mmHg increase in SBP and DBP was associated with a 1.45 (95% CI: 1.34-1.58) and 1.91 (95% CI: 1.68-2.18) risk, respectively. A U-shaped relationship was observed between heart failure/cardiomyopathy and BP. The associations between BP and risk of IHD, stroke, and any primary CVD were not statistically different comparing women with BC to controls, but risks varied by BC status for heart failure/cardiomyopathy ( Conclusions: Women with and without BC showed similar risks for IHD, stroke, and any primary CVD suggesting similar BP targets should be pursued regardless of BC survivorship status.

Indexed as

blood pressurebreast cancercardio-oncologycardiovascular outcomeshypertension

Identifiers

PMID39238853
PMCPMC11375265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.