Evidence map›Paper›PMID 39238729›Full record

ArticleCureus2024

Redefining Pulmonary Arterial Hypertension Treatment: Sotatercept's FDA Priority Review.

Harendra Kumar, Arkadeep Dhali, Jyotirmoy Biswas, Gopal Krishna Dhali

Abstract readEditorial
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Harendra KumarGeneral Medicine, Dow University of Health Sciences, Karachi, PAK.
Arkadeep DhaliInternal Medicine, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, GBR.
Jyotirmoy BiswasGeneral Medicine, College of Medicine and Sagor Dutta Hospital, Kolkata, IND.
Gopal Krishna DhaliGastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A biologics license application (BLA) for sotatercept, a therapeutic agent targeting activin receptor signaling implicated in pulmonary arterial hypertension (PAH), has been granted priority review status by the FDA. This advancement underscores the critical need for novel pharmacological interventions for this rare and severe condition, potentially transforming the therapeutic landscape of PAH.

Indexed as

activinoutcomepulmonary hypertensionsotatercepttherapy

Identifiers

PMID39238729
PMCPMC11375911

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.