Evidence map›Paper›PMID 39238625›Full record

ArticleCancer diagnosis & prognosis

Diagnostic Impacts of Aldehyde Dehydrogenase 2 Genetic Variants on Hepatocellular Carcinoma Susceptibility.

Yu-Ting Chin, Ming-Hsien Wu, Hou-Yu Shih, Chia-Wen Tsai, Jen-Sheng Pei, Tao-Wei Ke, Yun-Chi Wang, Yi-Chih Hung, Jaw-Chyun Chen, DA-Tian Bau and 1 more

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Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Ting Chin *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Ming-Hsien Wu *Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
Hou-Yu Shih *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Chia-Wen TsaiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Jen-Sheng PeiDepartment of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
Tao-Wei KeTerry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Yun-Chi WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Yi-Chih HungTerry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Jaw-Chyun ChenDepartment of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
DA-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Wen-Shin ChangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: The role of alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in hepatocellular carcinoma (HCC) development remains uncertain. Materials and Methods: We conducted genotyping of the ALDH2 rs671 single nucleotide polymorphism in 298 patients with HCC and 889 non-cancerous healthy controls. We assessed associations stratified by sex and alcohol consumption status. Results: Distribution of ALDH2 rs671 variant genotypes differed significantly between HCC patients and controls (p Conclusion: HCC risk is influenced by ALDH2 genotype, with effects modified by sex and alcohol consumption. Particularly, individuals with the ALDH2 rs671 AA genotype should avoid alcohol consumption, especially males.

Indexed as

Alcohol drinkingaldehyde dehydrogenase 2 (ALDH2)genotypehepatocellular carcinomapolymorphism

Identifiers

PMID39238625
PMCPMC11372694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.