Evidence map›Paper›PMID 39238425›Full record

ArticleJournal of surgical oncology2025

Implementation of Hepatic Artery Infusion Pump Therapy: Real-World Single-Center Experience.

Robert Connor Chick, Samantha M Ruff, Julia Monasterio, Taylor Neilson, Susan Tsai, Aslam Ejaz, Allan Tsung, Alex C Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert Connor ChickDivision of Surgical Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-5912-0902
Samantha M RuffDivision of Surgical Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.
Julia MonasterioCollege of Medicine, The Ohio State University, Columbus, Ohio, USA.
Taylor NeilsonDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Susan TsaiDivision of Surgical Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.
Aslam EjazDepartment of Surgery, Division of Surgical Oncology, University of Illinois Chicago, Chicago, Illinois, USA.
Allan TsungDepartment of Surgery, University of Virginia, Charlottesville, Virgina, USA.
Alex C KimDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesHepatic artery infusion pump (HAIP) therapy is an available option at highly specialized centers to treat unresectable liver tumors (e.g., colorectal liver metastases [CRLM]). This study describes the safety and outcomes of HAIP program implementation at an academic-based cancer center.

methodsPatients who underwent HAIP placement (2021-2023) were included. Categorical and continuous variables were compared using Chi-square and Kruska-Wallis tests, respectively. Survival and variables associated with survival were calculated using the Kaplan-Meier method and Cox proportional hazards model, respectively.

resultsOf the 26 HAIP procedures for unresectable CRLM, four were done as adjuvant therapy. Median duration of HAIP therapy was 9.2 months and four patients subsequently underwent hepatectomy. Complication rate was 37.5%, with biliary complication rate of 23.1%. Median overall survival (OS) from date of diagnosis was 55.2 months. Concurrent primary tumor resection was associated with inferior OS (p = 0.030). Multivariable regression did not identify independent predictors of OS. Progression-free survival from time of HAIP placement was 7.8 months.

conclusionsHAIP placement was technically successful in most patients with an acceptable complication rate. Survival outcomes were comparable with those described in the literature for HAIP therapy in combination with systemic therapy. The significant difference in outcomes for those with concurrent colectomy warrants further investigation.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsHepatic ArteryInfusion PumpsInfusions, Intra-ArterialLiver NeoplasmsAdultAgedFemaleFollow-Up StudiesHepatectomyHumansMaleMiddle AgedRetrospective StudiesSurvival Ratecolorectal liver metastasisfloxuridinehepatic arterial infusion pumpliver directed therapyregional therapies

Identifiers

PMID39238425
PMCPMC12035665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.