ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024
[Association between factors in life course and physiological dysregulation among the middle-aged and older population in Zhoushan city of Zhejiang province].
Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo analyze the associations between factors in life course and physiological dysregulation in the middle-aged and elderly population in Zhoushan city of Zhejiang province, and the mediating roles of lifestyle and mental health.
methodsA total of 1553 island residents aged ≥45 years were enrolled from the Zhejiang Metabolic Syndrome Cohort Zhoushan Liuheng Sub-cohort. The demographic information, life course information, lifestyle, and mental health information of the participants were documented and blood samples were collected. The status of aging was evaluated by physiological dysregulation calculation model previously developed by the authors. The Shapley value decomposition method was used to assess the cumulative and relative contribution of multiple factors in life course to the aging. Principal component analysis and hierarchical clustering analysis were used to classify subgroups. General linear regression model was used to assess associations between the life course subgroups and physiological dysregulation, and the key factors associated with aging were finally identified. Logistic regression model, general linear regression model, and mediation analysis model were used to assess the complex associations between life course subgroups, key factors, unhealthy lifestyle, mental health, and aging.
resultsShapley value decomposition method indicated that eight types of life course factors explained 6.63% (
conclusionsMultiple life course factors contribute about 6.63% of the variance in physiological dysregulation in the middle aged and elderly population of the study area; subgroups with adverse life course experiences have higher levels of aging; and the association may be partially mediated by unhealthy lifestyles.
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