Evidence map›Paper›PMID 39238265›Full record

ArticleAnatomical record (Hoboken, N.J. : 2007)2025

Alterations to peritubular capillary structure in a rat model of kidney interstitial fibrosis: Implications for oxygen diffusion.

Sarah E Gazzard, Luise A Cullen-McEwen, Marina Nikulina, Arnold B Clever, Bruce S Gardiner, David W Smith, Chang-Joon Lee, Jens R Nyengaard, Roger G Evans, John F Bertram

Abstract read
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In one paragraph

Article in Anatomical record (Hoboken, N.J. : 2007), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah E GazzardDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Luise A Cullen-McEwenDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-2229-5762
Marina NikulinaDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Arnold B CleverDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Bruce S GardinerSchool of Mathematics, Statistics, Chemistry and Physics, Murdoch University, Perth, Western Australia, Australia.
David W SmithFaculty of Engineering and Mathematical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Chang-Joon LeeAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Jens R NyengaardCore Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-8084-4646
Roger G EvansDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-9241-0757
John F BertramDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-5863-6464

Funding

Australian Research Council
6 · The paper itself

Abstract

Fibrosis and loss of functional capillary surface area may contribute to renal tissue hypoxia in a range of kidney diseases. However, there is limited quantitative information on the impact of kidney disease on the barriers to oxygen diffusion from cortical peritubular capillaries (PTCs) to kidney epithelial tubules. Here, we used stereological methods to quantify changes in total cortical PTC length and surface area, PTC length and surface densities, and diffusion distances between PTCs and kidney tubules in adenine-induced kidney injury. After 7 days of oral gavage of adenine (100 mg), plasma creatinine was 3.5-fold greater than in vehicle-treated rats, while total kidney weight was 83% greater. The total length of PTCs was similar in adenine-treated (1.47 ± 0.23 km (mean ± standard deviation)) to vehicle-treated (1.24 ± 0.24 km) rats, as was the surface density of PTCs (0.025 ± 0.002 vs. 0.024 ± 0.004 μm

Indexed as

CapillariesKidneyKidney DiseasesKidney TubulesOxygenAnimalsDiffusionDisease Models, AnimalFibrosisMaleRatsRats, Sprague-DawleyOxygenadeninecapillarykidneykidney interstitial fibrosisoxygen diffusion

Identifiers

PMID39238265
PMCPMC11967517

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.