ArticleJournal of animal science2025
Impact of different feed intake levels on intestinal morphology and epithelial cell differentiation in piglets.
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dietary Fermented Strawberry Pomace Improves Yolk Lipid Quality and Modulates Reproductive Endocrine Activity, Intestinal Barrier Status, and Cecal Microbiota in Laying Hens.Foods (Basel, Switzerland) · 2026Article
- Correlation between the barrier function of the intestinal epithelium and susceptibility to PEDV infection in piglets at different ages.Veterinary research · 2026Article
- Microbial regulation of intestinal stem cell function: implications for alleviating intestinal injury of weaned piglets.NPJ biofilms and microbiomes · 2026Review
- Effects of Host-Specific Multi-Lactic Acid Bacterial Probiotics on Performance, Carcass Traits, Meat Quality, and Gut Microbiome in Fattening Pigs.Veterinary sciences · 2026Article
- Early-life stages impact later feeding behavior and physiology in light-born piglets.Journal of animal science · 2026Article
- Colostrum increases DNA fractional synthetic rate, villi growth, and cellular proliferation of the jejunum in neonatal gilt piglets.Translational animal science · 2026Article
- APOBEC1-Dependent RNA Eiting of TNF Signaling Orchestrates Ileal Villus Morphogenesis in Pigs: Integrative Transcriptomic and Editomic Insights.Animals : an open access journal from MDPI · 2025Article
- Dihydromyricetin attenuates lipopolysaccharide-induced intestinal injury in weaned piglets by regulating oxidative stress and inhibiting NLRP3 inflammasome.Journal of animal science · 2025Article
- Feed restriction as a model for small intestinal permeability in nursery pigs.Journal of animal science · 2025Article
- Impact of initial postweaning feed intake on weanling piglet metabolism, gut health, and immunity.Journal of animal science · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
This study aimed to investigate the effect of feed intake levels on the development of intestinal morphology and epithelial cell differentiation in piglets. Sixty-four 35-d-old healthy weaned piglets ([Large White × Landrace] × Duroc) with an initial weight (6.93 ± 0.12 kg) were randomly divided into 4 groups (100%, 80%, 40%, and 20% feed intake) with 8 replicates of 2 pigs each. Samples were collected on days 3 and 7. The results revealed that with an increase in feed restriction degree and time, the body weight and organ index of piglets significantly decreased, and the villus height (VH) and crypt depth of the duodenum, jejunum, and ileum also decreased linearly (P < 0.05). After 3 d of feed restriction, jejunal ki67, endocrine cells, goblet cells, and villus endocrine/VH all decreased linearly, but the villus cup/VH ratio increased linearly, and the 40% and 20% were significantly higher than those of the 100% and 80% (P < 0.05). There was also a linear decrease in jejunal ki67, endocrine cells, goblet cells, and villous endocrine/VH in piglets fed 7 d of food restriction; however, the villus goblet cells/VH ratio in the 20% was significantly higher than that in the 40% group and was not different from that in the 80% (P < 0.05). During 3 d of feed restriction, the expression of jejunal differentiation marker genes showed a linear decreasing trend (P < 0.05) but increased linearly after 7 d of feed restriction. The expression levels of interleukin17 (IL-17) and IL-22 also increased linearly (P < 0.05). Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analysis analyses indicated that the PPAR signaling pathway, ECM-receptor interaction, and Th1, Th2, and Th17 cell differentiation were significantly enriched in these processes. real-time quantitative polymerase chain reaction demonstrated that both PPAR and ECM-receptor interactions were significantly activated during 7 d of feeding restriction (P < 0.05). The results showed that with an increase in feed restriction intensity and time, the intestinal morphology and epithelial cell proliferation and differentiation were significantly reduced, except for the goblet cells. This phenomenon is related to the regulation of intestinal differentiation by IL-17 and IL-22 secreted by the Th cells.
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