ArticleBMC psychiatry2024
Psychotic symptoms in Chinese adolescent patients with major depressive disorder: prevalence and related endocrine clinical factors.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The correlations between psychotic symptoms and childhood maltreatment as well as sex differences in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- The triglyceride-glucose index in relation to psychotic symptoms in adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Association Between Triglyceride-Glucose Index and Hyperuricemia in Hospitalized Patients with Depression: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
objectiveMajor depressive disorder (MDD) is often accompanied by psychotic symptoms. However, few studies have examined the relationship between psychotic symptoms and endocrine factors in adolescent patients with MDD. Therefore, this study aimed to investigate the prevalence and related endocrine clinical factors of psychotic symptoms in Chinese adolescent patients with MDD.
methodsIn total, 601 patients (aged 12-18) with MDD were recruited. The Patient Health Questionnaire - 9 items (PHQ - 9) was utilized for assessing depressive symptoms. Psychotic symptoms were assessed through clinical interviews. Prolactin (PRL), thyroid-stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), and free thyroxine (FT4) were also measured.
resultsThe incidence of psychotic symptoms in adolescent patients with MDD was 22.6%. The findings demonstrated that age, self-harming behavior, PHQ-9 score, FT4, and normalized PRL were independently associated with psychotic symptoms in patients with MDD (All p < 0.05).
conclusionsPRL and FT4 levels are more likely to be abnormally elevated in major depressive adolescents with psychotic symptoms. Prolactin and thyroid hormones in patients with MDD should be paid more attention.
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