Evidence map›Paper›PMID 39237914›Full record

Trial reportBMC pulmonary medicine2024

Delayed sustained lung inflation for preterm neonates in neonatal intensive care unit: a randomized controlled trial.

Li-Ting Lu, Ya-Wen Chiu, Mei-Yin Su, Hsiu-Feng Hsiao, Mei-Chin Yang, Yi-Hao Weng

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li-Ting LuDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Ya-Wen ChiuInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Mei-Yin Su *The Master Program of Sport Facility and Health Promotion, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei, 10617, Taiwan. meiyin@ntu.edu.tw.
Hsiu-Feng HsiaoDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Mei-Chin YangDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Yi-Hao Weng *Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. yihaoweng@cgmh.org.tw.

Funding

Chang Gung Memorial Hospital CMRPG1N0031National Science and Technology Council, Taiwan NSTC 112-2314-B-182A-106 -MY3
6 · The paper itself

Abstract

introductionSustained lung inflation (SLI) right after birth to decrease the use of mechanical ventilation of preterm infants is controversial because of potential harm. This randomized controlled trial was conducted to evaluate the effectiveness and safety of delayed SLI in neonatal intensive care unit (NICU).

methodsPreterm neonates requiring continuous positive airway pressure after birth were eligible for enrollment. In the experimental group, SLI with 20 cm H2O for 15 s was conducted by experienced staff in the NICU between 30 min and 24 h after birth.

resultsA total of 45 neonates were enrolled into this study, including 24 in the experimental group and 21 in the control group. There was no significant difference in the birth condition between the experimental and control groups, including gestational age (p = 0.151), birth weight (p = 0.692), and Apgar score at 1 min (p = 0.410) and 5 min (p = 0.518). The results showed the duration of respiratory support was shorter in the experimental group than the control group (p = 0.044). In addition, there was no significant difference in the other outcomes, such as pneumothorax, patent ductus arteriosus, and bronchopulmonary dysplasia.

conclusionOur findings indicate that sustained inflation conducted by experienced staff in the NICU is safe. The data suggest that SLI conducted by experienced staff in the NICU after stabilization could serve as an alternative management for preterm infants with respiratory distress. However, the reduction in use of respiratory support should be interpreted cautiously as a result of limited sample size.

trial registrationUniversity hospital Medical Information Network (UMIN) Clinical Trials Registry: UMIN000052797 (retrospectively registered).

Indexed as

Continuous Positive Airway PressureInfant, PrematureIntensive Care Units, NeonatalRespiratory Distress Syndrome, NewbornApgar ScoreBirth WeightFemaleGestational AgeHumansInfant, NewbornMaleRespiration, ArtificialTime FactorsNeonatal intensive care unitPreterm infantRandomized controlled trialRespiratory distressSustained lung inflation

Identifiers

PMID39237914
PMCPMC11378386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.