Evidence map›Paper›PMID 39237909›Full record

ArticleMolecular cancer2024

YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8

Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Molecular cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. mFrontiers in cell and developmental biology · 2026
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  16. Hypoxia-mediated mJournal of translational medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zhenyun Yang *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Xin Wang *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Yizhen Fu *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Weijie Wu *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Zili HuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Qingyang LinDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Wei PengDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Yangxun PanDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Juncheng WangDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Jinbin ChenDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Dandan HuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Zhongguo ZhouDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Li XuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Yaojun ZhangDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Jiajie HouCancer Centre, Faculty of Health Sciences, University of Macau, Macau, SAR, China. jiajiehou@um.edu.mo.
Minshan ChenDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China. chenmsh@sysucc.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritumoral hepatocytes are critical components of the liver cancer microenvironment, However, the role of peritumoral hepatocytes in the local tumor immune interface and the underlying molecular mechanisms have not been elucidated. YTHDF2, an RNA N

Indexed as

CD8-Positive T-LymphocytesChemokine CX3CL1HepatocytesLiver NeoplasmsOxaliplatinRNA-Binding ProteinsAdenosineAnimalsAntineoplastic AgentsCell Line, TumorGene Expression Regulation, NeoplasticHumansMembrane ProteinsMiceMice, KnockoutSignal TransductionAdenosineAntineoplastic AgentsChemokine CX3CL1CX3CL1 protein, humanCx3cl1 protein, mouseMembrane ProteinsOxaliplatinRNA-Binding Proteins

Identifiers

PMID39237909
PMCPMC11378438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.