Evidence map›Paper›PMID 39237686›Full record

ArticleScientific reports2024

Factors influencing mortality in intracranial infections caused by carbapenem-resistant Klebsiella Pneumoniae.

Chengcheng Lai, Zijun Ma, Yonggang Luo, Yuan Gao, Zhuanghao Wu, Jun Zhang, Weiwei Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chengcheng Lai *Department of General Practice, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zijun Ma *Department of General Practice, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yonggang LuoDepartment of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Luoyg_514@126.com.
Yuan GaoDepartment of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Zhuanghao WuDepartment of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Jun ZhangDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, China.
Weiwei XuDepartment of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Funding

Henan Province Key Medical Science and Technology Research Project Co-established by Provincial and Ministerial Authorities (CN) SBGJ202102081Henan Province Natural Science Foundation Project (CN) 242300420384Henan Province Science and Technology Research Project (CN) 242102311040Young and Middle-aged Scientific Technological Innovation Jie-Qing Talent Project YXKC2021042
6 · The paper itself

Abstract

It remains that intracranial infection has an alarming mortality and morbidity. Klebsiella pneumoniae (KP) have increasingly been isolated in ventriculitis and meningitis episodes. Intracranial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) account for high mortality. To understand its clinical impact and related risk factors accurately are crucial in the management of bacterial intracranial infection. The retrospective study aimed to delineate the clinical risk of death from intracranial infection and analyze the risk factors. A total of 176 Klebsiella pneumoniae intracranial infectious patients were available to divide into CRKP group and carbapenem-susceptive Klebsiella Pneumoniae (CSKP) group. We performed survival analysis and estimate the time-varying effects of CRKP and CSKP infection on 30-day mortality. Infectious patients caused by CSKP was associated with lower mortality than CRKP group. The risk factors associated with death from intracranial infection caused by Klebsiella pneumoniae included SOFA scores, ventilator therapy, CRKP, and heart failure. Longer hospital stays are independently associated with lower mortality rates. Intracranial infection caused by CRKP was associated with excess mortality. Complex comorbidities mean higher mortality. Active supportive treatment is required for complicated patients with intracranial infections caused by carbapenem-resistant Klebsiella pneumoniae.

Indexed as

CarbapenemsKlebsiella InfectionsKlebsiella pneumoniaeAdultAgedAnti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsAnti-Bacterial AgentsCarbapenemsCarbapenem-resistant Klebsiella PneumoniaeCarbapenem-susceptive Klebsiella PneumoniaeIntracranial infection

Identifiers

PMID39237686
PMCPMC11377438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.