Evidence map›Paper›PMID 39237673›Full record

ArticleScientific reports2024

Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction.

Kasen L Culler, Arjun Sinha, Mallory Filipp, Pedro Giro, Norrina B Allen, Kent D Taylor, Xiuqing Guo, Ed Thorp, Benjamin H Freed, Philip Greenland and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Serum Metabolites and Heart Failure Risk: MESA and RS.Journal of the American Heart Association · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Causal Associations Between Human Blood Metabolites and Cardio-Cerebrovascular Diseases: A Mendelian Randomisation Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kasen L CullerDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Arjun SinhaDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Mallory FilippDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Pedro GiroDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Norrina B AllenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ed ThorpDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Benjamin H FreedDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Wendy S PostDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alain BertoniDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
David HerringtonDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Chen GaoPhysiology and Pharmacology Department, University of Cincinnati, Cincinnati, OH, USA.
Yibin WangSignature Research Program of Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
Sanjiv J ShahDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Ravi B PatelDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA. ravi.patel@northwestern.edu.

Funding

Integrated Proteomic and Metabolomic Determinants of Left Atrial DysfunctionR01HL167986 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ravi Bharat Patel · 2024 to 2026
$1.9M
NHLBI NIH HHS R01 HL167986
6 · The paper itself

Abstract

Metabolic comorbidities, such as obesity and diabetes, are associated with subclinical alterations in both cardiac structure/function and natriuretic peptides prior to the onset of heart failure (HF). Despite this, the exact metabolic pathways of cardiac dysfunction which precede HF are not well-defined. Among older individuals without HF in the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated the associations of 47 circulating metabolites measured by

Indexed as

Heart FailureMetabolomicsAgedAged, 80 and overBiomarkersEchocardiographyFemaleHumansInositolMaleMetabolomeMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsStroke VolumeBiomarkersInositolNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Cardiac structureEchocardiographyGeneticsHeart failureMetabolomicsMyo-inositolNatriuretic peptide

Identifiers

PMID39237673
PMCPMC11377834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.