Evidence map›Paper›PMID 39237663›Full record

ArticleScientific reports2024

The histone H3K9 methyltransferase G9a regulates tendon formation during development.

Satoshi Wada, Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Noboru Demura, Hiroshi Tomonari, Hiroshi Kimura, Makoto Tachibana, Akira Nifuji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Satoshi Wada *Department of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan.
Hisashi Ideno *Department of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan.
Kazuhisa NakashimaDepartment of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan.
Koichiro KomatsuDepartment of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan.
Noboru DemuraDepartment of Oral and Maxillofacial Surgery, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
Hiroshi TomonariDepartment of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan.
Hiroshi KimuraDepartment of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, 226-8501, Japan.
Makoto TachibanaLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565-0871, Japan.
Akira NifujiDepartment of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa, 230-8501, Japan. nifuji-a@tsurumi-u.ac.jp.

Funding

Japan Society for the Promotion of Science 15K15679Japan Society for the Promotion of Science 16K11797Japan Society for the Promotion of Science 18K09515Japan Society for the Promotion of Science 20K09897Japan Society for the Promotion of Science 21K09823Japan Society for the Promotion of Science 21K10199Japan Society for the Promotion of Science 22390344Japan Society for the Promotion of Science 23K09158
6 · The paper itself

Abstract

G9a is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9 (H3K9), which is involved in the regulation of gene expression. We had previously reported that G9a is expressed in developing tendons in vivo and in vitro and that G9a-deficient tenocytes show impaired proliferation and differentiation in vitro. In this study, we investigated the functions of G9a in tendon development in vivo by using G9a conditional knockout (G9a cKO) mice. We crossed Sox9

Indexed as

Cell DifferentiationCell ProliferationHistone-Lysine N-MethyltransferaseMice, KnockoutTendonsAnimalsCollagen Type ICollagen Type I, alpha 1 ChainGene Expression Regulation, DevelopmentalHistonesMembrane ProteinsMiceSOX9 Transcription FactorTenocytesCollagen Type ICollagen Type I, alpha 1 ChainG9a protein, mouseHistone-Lysine N-MethyltransferaseHistonesMembrane ProteinsSOX9 Transcription FactorTnmd protein, mouseCell differentiationEpigeneticsHistone modificationProliferationTenocytes

Identifiers

PMID39237663
PMCPMC11377446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.