Evidence map›Paper›PMID 39237596›Full record

ArticleNPJ precision oncology2024

Cross-modal deep learning model for predicting pathologic complete response to neoadjuvant chemotherapy in breast cancer.

Jianming Guo, Baihui Chen, Hongda Cao, Quan Dai, Ling Qin, Jinfeng Zhang, Youxue Zhang, Huanyu Zhang, Yuan Sui, Tianyu Chen and 3 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianming GuoDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.ORCID http://orcid.org/0009-0009-6535-9317
Baihui ChenDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Hongda CaoSchool of Computer, Beihang University, 100191, Beijing, China.
Quan DaiMedicine & Laboratory of Translational Research in Ultrasound Theranostics, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, 610041, Chengdu, China.
Ling QinDepartment of Pathology, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Jinfeng ZhangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Youxue ZhangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Huanyu ZhangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Yuan SuiDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Tianyu ChenDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Dongxu YangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Xue GongDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China.
Dalin LiDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, 150000, Harbin, China. lidalin1975@163.com.ORCID http://orcid.org/0000-0002-6474-5998

Funding

Ministry of Health of China | Wu Jieping Medical Foundation 320.6750.2023-11-10
6 · The paper itself

Abstract

Pathological complete response (pCR) serves as a critical measure of the success of neoadjuvant chemotherapy (NAC) in breast cancer, directly influencing subsequent therapeutic decisions. With the continuous advancement of artificial intelligence, methods for early and accurate prediction of pCR are being extensively explored. In this study, we propose a cross-modal multi-pathway automated prediction model that integrates temporal and spatial information. This model fuses digital pathology images from biopsy specimens and multi-temporal ultrasound (US) images to predict pCR status early in NAC. The model demonstrates exceptional predictive efficacy. Our findings lay the foundation for developing personalized treatment paradigms based on individual responses. This approach has the potential to become a critical auxiliary tool for the early prediction of NAC response in breast cancer patients.

Identifiers

PMID39237596
PMCPMC11377584

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.