Evidence map›Paper›PMID 39237580›Full record

ArticleScientific reports2024

Large language multimodal models for new-onset type 2 diabetes prediction using five-year cohort electronic health records.

Jun-En Ding, Phan Nguyen Minh Thao, Wen-Chih Peng, Jian-Zhe Wang, Chun-Cheng Chug, Min-Chen Hsieh, Yun-Chien Tseng, Ling Chen, Dongsheng Luo, Chenwei Wu and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jun-En Ding *School of Systems and Enterprises, Stevens Institute of Technology, Hoboken, USA.
Phan Nguyen Minh Thao *Department of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Wen-Chih PengDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Jian-Zhe WangDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Chun-Cheng ChugDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Min-Chen HsiehDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Yun-Chien TsengDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Ling ChenInstitute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Dongsheng LuoSchool of Computing and Information Science, Florida International University, Miami, USA.
Chenwei WuElectrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.
Chi-Te WangCenter of Artificial Intelligence, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Chih-Ho HsuDepartment of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Yi-Tui ChenSmart Healthcare Interdisciplinary College, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
Pei-Fu ChenDepartment of Anesthesiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Feng LiuSchool of Systems and Enterprises, Stevens Institute of Technology, Hoboken, USA.
Fang-Ming HungSurgical Trauma Intensive Care Unit, Far Eastern Memorial Hospital, New Taipei City, Taiwan. philip@mail.femh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a prevalent health challenge faced by countries worldwide. In this study, we propose a novel large language multimodal models (LLMMs) framework incorporating multimodal data from clinical notes and laboratory results for diabetes risk prediction. We collected five years of electronic health records (EHRs) dating from 2017 to 2021 from a Taiwan hospital database. This dataset included 1,420,596 clinical notes, 387,392 laboratory results, and more than 1505 laboratory test items. Our method combined a text embedding encoder and multi-head attention layer to learn laboratory values, and utilized a deep neural network (DNN) module to merge blood features with chronic disease semantics into a latent space. In our experiments, we observed that integrating clinical notes with predictions based on textual laboratory values significantly enhanced the predictive capability of the unimodal model in the early detection of T2DM. Moreover, we achieved an area greater than 0.70 under the receiver operating characteristic curve (AUC) for new-onset T2DM prediction, demonstrating the effectiveness of leveraging textual laboratory data for training and inference in LLMs and improving the accuracy of new-onset diabetes prediction.

Indexed as

Diabetes Mellitus, Type 2Electronic Health RecordsCohort StudiesDatabases, FactualDeep LearningFemaleHumansMaleMiddle AgedNeural Networks, ComputerROC CurveTaiwan

Identifiers

PMID39237580
PMCPMC11377777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.