Evidence map›Paper›PMID 39237365›Full record

ArticleLife science alliance2024

Regulation of proteostasis by sleep through autophagy in

Natalie Ortiz-Vega, Amanda G Lobato, Tijana Canic, Yi Zhu, Stanislav Lazopulo, Sheyum Syed, R Grace Zhai

Abstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  7. The effects of obesogenic diet on amicroPublication biology · 2026
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalie Ortiz-VegaDepartment of Neurology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-3520-2644
Amanda G LobatoDepartment of Neurology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-4218-7817
Tijana CanicDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0009-0005-3941-8409
Yi ZhuDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-1778-8880
Stanislav LazopuloDepartment of Physics, University of Miami, Coral Gables, FL, USA.ORCID 0000-0002-1834-4368
Sheyum SyedDepartment of Physics, University of Miami, Coral Gables, FL, USA.ORCID 0000-0002-4642-6678
R Grace ZhaiDepartment of Neurology, University of Chicago, Chicago, IL, USA rgzhai@uchicago.edu.ORCID 0000-0002-7599-1430

Funding

microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic PainR33AT010408 · NCCIH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHAI, RONG GRACE · 2022 to 2024
$2.1M
NCCIH NIH HHS R33 AT010408
6 · The paper itself

Abstract

Sleep and circadian rhythm dysfunctions are common clinical features of Alzheimer's disease (AD). Increasing evidence suggests that in addition to being a symptom, sleep disturbances can also drive the progression of neurodegeneration. Protein aggregation is a pathological hallmark of AD; however, the molecular pathways behind how sleep affects protein homeostasis remain elusive. Here we demonstrate that sleep modulation influences proteostasis and the progression of neurodegeneration in

Indexed as

Alzheimer DiseaseAutophagyDisease Models, AnimalProteostasisSleeptau ProteinsAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsHumansNeuronsSleep DeprivationTauopathiesDrosophila Proteinstau Proteins

Identifiers

PMID39237365
PMCPMC11377308

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.