Evidence map›Paper›PMID 39236955›Full record

ArticleInternational journal of biological macromolecules2024

Formulating a TMEM176B blocker in chitosan nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

Sabina Victoria, Analía Castro, Alvaro Pittini, Daniela Olivera, Sofía Russo, Ignacio Cebrian, Alvaro W Mombru, Eduardo Osinaga, Helena Pardo, Mercedes Segovia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  5. Article
  6. Review
  7. The intracellular cation channel TMEM176B as a dual immunoregulator.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sabina VictoriaLaboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Analía CastroCentro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 9100 Pando, Canelones, Uruguay.
Alvaro PittiniImmunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay; Laboratory of Tumor Immunology and Glycobiology, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Daniela OliveraLaboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay.
Sofía RussoLaboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay.
Ignacio CebrianFacultad de Ciencias Médicas, Instituto de Histología y Embriología de Mendoza (IHEM)-CONICET/Universidad Nacional de Cuyo, Mendoza, Argentina.
Alvaro W MombruCentro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 9100 Pando, Canelones, Uruguay.
Eduardo OsinagaImmunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay; Laboratory of Tumor Immunology and Glycobiology, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Helena PardoCentro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 9100 Pando, Canelones, Uruguay. Electronic address: hpardo@fq.edu.uy.
Mercedes SegoviaLaboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: msegovia@pasteur.edu.uy.
Marcelo HillLaboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: mhill@pasteur.edu.uy.

Funding

Characterization of an inflammasome-unleashing approach to improve anti-PD-1 therapy in cancerR21CA263424 · NCI · ARDAN PHARMA S A S · PI HILL, MARCELO · 2021 to 2022
$275k
NCI NIH HHS R21 CA263424
6 · The paper itself

Abstract

The immunoregulatory cation channel TMEM176B plays a dual role in tumor immunity. On the one hand, TMEM176B promotes antigen cross-presentation to CD8

Indexed as

Adaptive ImmunityChitosanDendritic CellsImmunity, InnateNanoparticlesAnimalsCD8-Positive T-LymphocytesCell Line, TumorInflammasomesMelanoma, ExperimentalMembrane ProteinsMiceMice, Inbred C57BLPolyethylene GlycolsChitosanInflammasomesMembrane ProteinsPolyethylene GlycolsChitosan nanoparticlesCross-presentationInflammasomeNanoencapsulationTMEM176BTumor immunity

Identifiers

PMID39236955
PMCPMC11469942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.