Evidence map›Paper›PMID 39236902›Full record

ArticleThe Journal of investigative dermatology2025

Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing.

Daniel C Stewart, Becky K Brisson, William K Yen, Yuchen Liu, Chao Wang, Gordon Ruthel, Donald Gullberg, Robert L Mauck, Malcolm Maden, Lin Han and 1 more

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Behavioral and Functional Profiling ofbioRxiv : the preprint server for biology · 2026
    Article
  7. Loss of type III collagen has limited effect on tendon healing in young adult mice.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Article
  8. Article
  9. Article
  10. Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Cu-CeOFrontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel C StewartDepartment of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Becky K BrissonDepartment of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
William K YenDepartment of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Yuchen LiuSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Chao WangSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Gordon RuthelDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Donald GullbergThe Department of Biomedicine, University of Bergen, Bergen, Norway; Centre for Cancer Biomarkers (CCBIO), Norwegian Centre of Excellence, University of Bergen, Bergen, Norway.
Robert L MauckDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
Malcolm MadenDepartment of Biology, College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida, USA.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Susan W VolkDepartment of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: swvolk@vet.upenn.edu.

Funding

Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
The regulatory roles of type III collagen in cutaneous wound healingR01GM124091 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI VOLK, SUSAN W · 2018 to 2022
$2.1M
Building Enhanced Capability for the PennVet Multiphoton CoreS10OD021633 · OD · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2016 to 2016
$600k
FLIM system, resonant scanner, and UV laser for 2 photon microscopeS10RR027128 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2010 to 2010
$496k
NCRR NIH HHS S10 RR027128NIAMS NIH HHS P30 AR069589NIGMS NIH HHS R01 GM124091NIH HHS S10 OD021633
6 · The paper itself

Abstract

Postnatal cutaneous wound healing is characterized by development of a collagen-rich scar lacking the architecture and functional integrity of unwounded tissue. Directing cell behaviors to efficiently heal wounds while minimizing scar formation remains a major wound management goal. In this study, we demonstrate type III collagen (COL3) as a critical regulator of re-epithelialization and scar formation during healing of COL3-enriched, regenerative (Acomys), scar-permissive (CD-1 Mus and wild-type Col3

Indexed as

CicatrixCollagen Type IIIExtracellular MatrixMechanotransduction, CellularSkinWound HealingAnimalsDisease Models, AnimalMiceMice, Inbred C57BLRe-EpithelializationCollagen Type IIIExtracellular matrixMechanotransudctionRegenerationScarTissue engineering

Identifiers

PMID39236902
PMCPMC12359077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.