Evidence map›Paper›PMID 39236785›Full record

ArticleMolecular metabolism2024

Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.

Romana Stark, Harry Dempsey, Elizabeth Kleeman, Martina Sassi, Sherri Osborne-Lawrence, Sepideh Sheybani-Deloui, Helen J Rushby, Christen K Mirth, Karl Austin-Muttitt, Jonathan Mullins and 3 more

Abstract read
In one paragraph

Article in Molecular metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Romana StarkMonash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia. Electronic address: Romana.Stark@monash.edu.
Harry DempseyMonash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia.
Elizabeth KleemanThe Florey Institute of Neuroscience and Mental Health, Mental Health Division, Parkville, Melbourne, Australia.
Martina SassiInstitute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Sherri Osborne-LawrenceCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Sepideh Sheybani-DelouiCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Helen J RushbySchool of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Christen K MirthSchool of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Karl Austin-MuttittInstitute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Jonathan MullinsInstitute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Jeffrey M ZigmanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Jeffrey S DaviesInstitute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Zane B AndrewsMonash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia. Electronic address: Zane.Andrews@monash.edu.

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

objectiveAlthough the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism.

methodsWe performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OB

resultsOB

conclusionsOB

Indexed as

Feeding BehaviorHungerOlfactory BulbAnimalsExploratory BehaviorMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, GhrelinSignal TransductionSmellReceptors, GhrelinAnxietyGhrelinGlutamateHungerMetabolismOlfactionOlfactory bulbTranscriptomics

Identifiers

PMID39236785
PMCPMC11471258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.