Evidence map›Paper›PMID 39236696›Full record

ArticleNeuroepidemiology2025

Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older Adults: The Shanghai Aging Study.

Ding Ding, Su Liu, Jianfeng Luo, Zhenxu Xiao, Wanqing Wu, Xiaoniu Liang, Qianhua Zhao, Xianfeng Zhao, Yi Wang, Wenhuan Fu and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroepidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ding Ding
Su LiuDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China, sliu20@fudan.edu.cn.
Jianfeng LuoDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Zhenxu XiaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Wanqing WuInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoniu LiangInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Qianhua ZhaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xianfeng ZhaoDanone Open Science Research Center for Life-Transforming Nutrition, Shanghai, China.
Yi WangDanone Open Science Research Center for Life-Transforming Nutrition, Shanghai, China.
Wenhuan FuDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.
Ding DingInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrevious longitudinal studies reported the impact of antioxidant nutrients (ANs) on cognitive impairment in the older population, but the conclusions were inconsistent. This study aimed to verify the hypothesis that dietary intake of total AN was associated with incident dementia among older individuals.

methodsCommunity residents without dementia aged ≥60 years were prospectively followed up for an average of 5.2 years in the Shanghai Aging Study. At baseline, daily intakes of total dietary AN (the sum of carotene, vitamin C, vitamin E, lutein, and flavonoids) and energy were calculated based on an interviewer-administered food frequency questionnaire measuring the dietary intake over the past 1 year for each participant. A battery of neuropsychological tests was used to evaluate cognitive function, and a consensus diagnosis of dementia was made according to the DSM-IV criteria at baseline and follow-up.

resultsAmong 1,550 dementia-free participants, 135 (8.7%) incident dementia cases were identified during the average of 5.2 years of follow-up. Participants with low AN intake (<112 mg/day) had a significantly higher risk of incident dementia than those with high AN intake (≥112 mg/day) (hazard ratio 1.87, 95% confidence interval 1.26-2.77) after adjusting for age, gender, education, obesity, APOE-ε4, hypertension, diabetes, depression, baseline Mini-Mental State Examination score, and total energy intake. The significant association of total AN intake with incident dementia was only found in individuals ≥70 years.

conclusionLow total AN intake may be a risk factor for incident dementia among older adults. Maintaining sufficient AN intake may be beneficial against age-related cognitive decline.

Indexed as

AgingAntioxidantsDementiaDietNutrientsAgedAged, 80 and overChinaFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsAntioxidantsNutrientsAntioxidant nutrientsCognitionDementiaDietary intakeOlder adults

Identifiers

PMID39236696
PMCPMC12500277

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