SynthesisEuropean journal of neurology2024
Risk of aspiration pneumonia and hospital mortality in Parkinson disease: A systematic review and meta-analysis.
Synthesis in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systemic Review and Meta-Analysis of the Risk of Venous Thromboembolic Events in Parkinson's Patients.European journal of neurology · 2025Pooled it
- Risk of aspiration pneumonia and hospital mortality in Parkinson disease: A systematic review and meta-analysis.European journal of neurology · 2024Pooled it
- Patterns of spontaneous saliva swallowings during awake and sleep states in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Human-AI collaboration for dysphagia rehabilitation from effectiveness to implementation complexity: a systematic review.NPJ digital medicine · 2026Article
- Multi-dimensional risk prediction and genetic architecture of aspiration pneumonia: a population-based analysis.BMC infectious diseases · 2026Article
- Role of Respiratory Pressure in Swallowing Function and Aspiration Risk in Parkinsonism.Dysphagia · 2026Article
- Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Real-world analysis and future trends of parkinson's disease burden and all-cause mortality in Shanghai Pudong: a population-based study of 3.17 million people.BMC public health · 2025Article
- Article
- Far from being the end of the road: taking a closer look at neuropalliative care in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Article
- Comorbidities and their impact on in-hospital mortality in hospitalized adult patients with bacterial community-acquired pneumonia: a cohort study.Journal of thoracic disease · 2025Article
- Obstructive Sleep Apnea and Parkinson's Disease: Bidirectional Clinical and Pathophysiologic Links.International journal of molecular sciences · 2025Review
- Anesthetic management in the lateral position in a patient with Parkinson's disease who developed severe long-seated forward flexion with the face buried between the knees: a case report.JA clinical reports · 2025Article
- A Systematic Review and Meta-Analysis of Non-Invasive Nerve Stimulation Interventions on Dysphagia in Patients with Parkinson's Disease.Neuropsychiatric disease and treatment · 2025Review
- Botulinum toxin A for sialorrhea in adults with neurological disorders: a narrative review of aspiration pneumonia risk.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
background and purposeThis study was undertaken to conduct a meta-analysis on the prevalence of aspiration pneumonia (AP) and hospital mortality in Parkinson disease (PD) as well as the risk of AP in PD patients compared to controls.
methodsWe searched MEDLINE and Embase from inception to 19 March 2024 to identify cross-sectional, cohort, and case-control studies comparing the frequency of AP and hospital mortality in PD patients. We computed risk ratios (RRs) with accompanying 95% confidence intervals (CIs) for each study and pooled the results using a random-effects meta-analysis.
resultsA total of 781 studies were initially screened, and 13 studies involving 541,785,587 patients were included. Patients with PD had >3 times higher risk of AP compared to controls (RR = 3.30, 95% CI = 1.82-6.00, p < 0.0001). This increased risk was similar in both cohort studies (RR = 3.01, 95% CI = 1.10-8.24, p = 0.03) and case-control studies (RR = 3.86, 95% CI = 3.84-3.87, p < 0.00001). The prevalence of AP in 12 studies was 2.74% (95% CI = 1.69-4.41), and hospital mortality was 10% in six studies (10.0%, 95% CI = 5.32-18.0). Prevalence of AP was higher in studies with smaller sample size (5.26%, 95% CI = 3.08-8.83 vs. 2.06%, 95% CI = 1.19-3.55, p = 0.02).
conclusionsOur meta-analysis showed that patients with PD had >3 times higher risk of AP, with an average 2.74% prevalence and 10.0% hospital mortality. Early recognition and treatment of AP in PD patients will help reduce morbidity and mortality. A multidisciplinary holistic approach is needed to address the multifactorial causes of AP.
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