Evidence map›Paper›PMID 39236283›Full record

Trial reportJCO global oncology2024

Potential of E-Learning Interventions and Artificial Intelligence-Assisted Contouring Skills in Radiotherapy: The ELAISA Study.

Mathis Ersted Rasmussen, Kamal Akbarov, Egor Titovich, Jasper Albertus Nijkamp, Wouter Van Elmpt, Hanne Primdahl, Pernille Lassen, Jon Cacicedo, Lisbeth Cordero-Mendez, A F M Kamal Uddin and 24 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in JCO global oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Quantifying manual editing time in autocontouring via audit log analysis.Physics and imaging in radiation oncology · 2026
    Article
  4. Article
  5. Article
  6. Enhancing Radiation Oncology Education Through Artificial Intelligence: A Review of Applications, Limitations, and Future Directions.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Mathis Ersted RasmussenExperimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-7853-3531
Kamal AkbarovInternational Atomic Energy Agency, Vienna, Austria.ORCID 0000-0002-5667-8932
Egor TitovichInternational Atomic Energy Agency, Vienna, Austria.ORCID 0009-0007-9941-2329
Jasper Albertus NijkampDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-7523-5881
Wouter Van ElmptMAASTRO clinic, Maastricht University Medical Centre, Maastricht, the Netherlands.ORCID 0000-0001-8820-0784
Hanne PrimdahlDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Pernille LassenDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Jon CacicedoDepartment of Radiation Oncology, Cruces University Hospital, Bilbao, Spain.
Lisbeth Cordero-MendezInternational Atomic Energy Agency, Vienna, Austria.
A F M Kamal UddinLabaid Cancer Hospital and Super Speciality Centre, Dhaka, Bangladesh.
Ahmed MohamedNational Cancer Institute, University of Gezira, Wad Madani, Sudan.ORCID 0009-0001-5675-5707
Ben PrajogiCipto Mangunkusumo Hospital, Jakarta, Indonesia.ORCID 0000-0001-9615-3084
Kartika Erida BrohetDharmais Cancer Hospital, Jakarta, Indonesia.ORCID 0009-0009-9514-9222
Catherine NyongesaKenyatta National Hospital, Nairobi, Kenya.
Darejan LomidzeTbilisi State Medical University and Ingorokva High Medical Technology University Clinic, Tbilisi, Georgia.
Gisupnikha PrasikoNepal Cancer Hospital and Research Center, Lalitpur, Nepal.
Gustavo FerrarisCentro de Radioterapiya dean Funes, Cordoba, Argentina.ORCID 0000-0003-3862-9296
Humera MahmoodAtomic Energy Cancer Hospital NORI, Islamabad, Pakistan.
Igor StojkovskiUniversity Clinic of Radiotherapy and Oncology, Skopje, Macedonia.ORCID 0000-0002-5770-2578
Isa IsayevNational Center of Oncology, Baku, Azerbaijan.
Issa MohamadKing Hussein Cancer Center, Amman, Jordan.ORCID 0000-0003-0153-9131
Leivon ShirleyChristian Institute of Health Science and Research, Dimapur, India.ORCID 0000-0002-5030-0728
Lotfi KochbatiHospital Abderrahmen Mami, Ariana, Tunesia.
Ludmila EftodievMoldavian Oncology Institute, Chisinau, Moldova.
Maksim PiatkevichN. N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.ORCID 0000-0002-5137-3064
Maria Matilde Bonilla JaraHospital México, San José, Costa Rica.
Orges SpahiuMother Tereza Hospital, Tirana, Albania.ORCID 0000-0003-1010-3743
Rakhat AralbayevNational Centre of Oncology and Hematology, Bishkek, Kyrgyzstan.
Raushan ZakirovaCenter of Nuclear Medicine and Oncology, Semey, Kazakhstan.ORCID 0009-0008-0462-6875
Sandya SubramaniamHospital Kuala Lumpur, Kuala Lumpur, Malaysia.ORCID 0000-0003-0546-7024
Solomon KibuddeUganda Cancer Institute, Kampala, Uganda.ORCID 0000-0002-4013-2476
Uranchimeg TsegmedNational Cancer Center of Mongolia, Ulaanbaatar, Mongolia.
Stine Sofia KorremanDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3523-382X
Jesper Grau EriksenExperimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-1145-6033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost research on artificial intelligence-based auto-contouring as template (AI-assisted contouring) for organs-at-risk (OARs) stem from high-income countries. The effect and safety are, however, likely to depend on local factors. This study aimed to investigate the effects of AI-assisted contouring and teaching on contouring time and contour quality among radiation oncologists (ROs) working in low- and middle-income countries (LMICs). MATERIALS AND

methodsNinety-seven ROs were randomly assigned to either manual or AI-assisted contouring of eight OARs for two head-and-neck cancer cases with an in-between teaching session on contouring guidelines. Thereby, the effect of teaching (yes/no) and AI-assisted contouring (yes/no) was quantified. Second, ROs completed short-term and long-term follow-up cases all using AI assistance. Contour quality was quantified with Dice Similarity Coefficient (DSC) between ROs' contours and expert consensus contours. Groups were compared using absolute differences in medians with 95% CIs.

resultsAI-assisted contouring without previous teaching increased absolute DSC for optic nerve (by 0.05 [0.01; 0.10]), oral cavity (0.10 [0.06; 0.13]), parotid (0.07 [0.05; 0.12]), spinal cord (0.04 [0.01; 0.06]), and mandible (0.02 [0.01; 0.03]). Contouring time decreased for brain stem (-1.41 [-2.44; -0.25]), mandible (-6.60 [-8.09; -3.35]), optic nerve (-0.19 [-0.47; -0.02]), parotid (-1.80 [-2.66; -0.32]), and thyroid (-1.03 [-2.18; -0.05]). Without AI-assisted contouring, teaching increased DSC for oral cavity (0.05 [0.01; 0.09]) and thyroid (0.04 [0.02; 0.07]), and contouring time increased for mandible (2.36 [-0.51; 5.14]), oral cavity (1.42 [-0.08; 4.14]), and thyroid (1.60 [-0.04; 2.22]).

conclusionThe study suggested that AI-assisted contouring is safe and beneficial to ROs working in LMICs. Prospective clinical trials on AI-assisted contouring should, however, be conducted upon clinical implementation to confirm the effects.

Indexed as

Artificial IntelligenceAdultFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedOrgans at RiskRadiation OncologistsRadiotherapy Planning, Computer-Assisted

Identifiers

PMID39236283
PMCPMC11404336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.