ArticleScience (New York, N.Y.)2024
Achieving optical transparency in live animals with absorbing molecules.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06800183 (Topical Application of Tartrazine for Enhanced Visualization of Subcutaneous Structures in Dermatology), which is not on this map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Application of Tartrazine for Enhanced Visualization of Subcutaneous Structures in Dermatology
Who cites it
89 citing papers in PubMed.
- Field-Driven Active Colloids as Distributed Micromachines: Bridging Physics, Control, and Function Across Length Scales.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamicsbioRxiv : the preprint server for biology · 2026Article
- A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals.Science advances · 2026Article
- Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Optical performance of minimally invasive brain implants: a simulation and phantom study.Biomedical optics express · 2026Article
- The meta way of thinking.Nature materials · 2026Article
- Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice.Nature communications · 2026Article
- Tartrazine Clears Live Cells while Preserving Viability at High Refractive Indices and Osmolality.Bioconjugate chemistry · 2026Article
- In vivo tissue clearing with tartrazine and other dye molecules.Communications biology · 2026Review
- Comparing the Effects of Chemical Optical Clearing Agents and Mechanical Compression on the Optical Attenuation of Porcine Skin.Journal of biophotonics · 2026Article
- Protocol for ultrafast immunolabeling and 3D imaging of whole organs and large tissues.STAR protocols · 2026Article
- Advancing small-animal molecular imaging through multifaceted innovation.Journal of biomedical optics · 2026Article
- Enhancing the efficiency of achieving optical transparency in live animals using absorbing molecules.Journal of biomedical optics · 2026Article
- 3D Single-Virus Tracking: Advances in Methodology and Labeling Strategies Towards Probing the Virus-Epithelium Interaction.Viruses · 2026Review
- Digital defocus aberration interference for automated optical microscopy.Nature communications · 2026Article
- Tartrazine clears live cells while preserving viability at high refractive indices and osmolality.bioRxiv : the preprint server for biology · 2026Article
- A simple and reliable method for the qualitative and quantitative analysis of nano- and microplastics in organs for controlled preclinical studies.Particle and fibre toxicology · 2026Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors.
Funding
Abstract
Optical imaging plays a central role in biology and medicine but is hindered by light scattering in live tissue. We report the counterintuitive observation that strongly absorbing molecules can achieve optical transparency in live animals. We explored the physics behind this observation and found that when strongly absorbing molecules dissolve in water, they can modify the refractive index of the aqueous medium through the Kramers-Kronig relations to match that of high-index tissue components such as lipids. We have demonstrated that our straightforward approach can reversibly render a live mouse body transparent to allow visualization of a wide range of deep-seated structures and activities. This work suggests that the search for high-performance optical clearing agents should focus on strongly absorbing molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.