Evidence map›Paper›PMID 39235960›Full record

ArticleJournal of bacteriology2024

Overexpression of diglucosyldiacylglycerol synthase leads to daptomycin resistance in

Ryogo Yamamoto, Kazuya Ishikawa, Yusuke Miyoshi, Kazuyuki Furuta, Shin-Ichi Miyoshi, Chikara Kaito

Abstract read
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryogo YamamotoGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Kazuya IshikawaGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID 0000-0003-0135-8891
Yusuke MiyoshiGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Kazuyuki FurutaGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID 0000-0003-4068-8367
Shin-Ichi MiyoshiGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Chikara KaitoGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID 0000-0002-2895-3386

Funding

Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care (Ichiro Kanehara Foundation)Japan Agency for Medical Research and Development (AMED) JP23wm0125004MEXT | Japan Society for the Promotion of Science (JSPS) 22K14892MEXT | Japan Society for the Promotion of Science (JSPS) 23K06130MEXT | Japan Society for the Promotion of Science (JSPS) 23K24131MEXT | Japan Society for the Promotion of Science (JSPS) 24K01760Ryobi Teien Memory Foundation (Ryobi Teien Memorial Foundation)Takeda Science Foundation (TSF)
6 · The paper itself

Abstract

The lipopeptide antibiotic daptomycin exhibits bactericidal activity against Gram-positive bacteria by forming a complex with phosphatidylglycerol (PG) and lipid II in the cell membrane, causing membrane perforation. With the emergence of daptomycin-resistant bacteria, understanding the mechanisms of bacterial resistance to daptomycin has gained great importance. In this study, we aimed to identify the genetic factors contributing to daptomycin resistance in

Indexed as

Anti-Bacterial AgentsBacillus subtilisBacterial ProteinsDaptomycinDrug Resistance, BacterialGene Expression Regulation, BacterialMicrobial Sensitivity TestsPhosphatidylglycerolsAnti-Bacterial AgentsBacterial ProteinsDaptomycinPhosphatidylglycerolsdaptomycindiglucosyldiacylglycerolphospholipid

Identifiers

PMID39235960
PMCPMC11500525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.