Evidence map›Paper›PMID 39235664›Full record

ReviewMedical oncology (Northwood, London, England)2024

Current diagnostic and quantitative techniques in the field of lymphedema management: a critical review.

Mary Vargo, Melissa Aldrich, Paula Donahue, Emily Iker, Louise Koelmeyer, Rachelle Crescenzi, Andrea Cheville

Abstract readReview
In one paragraph

Review in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Response to comment 'Comment on "The effects of early rehabilitation on physical and psychosocial functions after breast cancer surgery"'.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Advancing Lymphedema Surveillance With Evidence-Based Practices.Clinical journal of oncology nursing · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary VargoDepartment of Physical Medicine and Rehabilitation, MetroHealth Rehabilitation Institute, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-6286-6876
Melissa AldrichCenter for Molecular Imaging, UTHealth, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8114-7607
Paula DonahueDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4656-6539
Emily IkerLymphedema Center, Santa Monica, CA, USA.ORCID http://orcid.org/0000-0002-6882-1089
Louise KoelmeyerAustralian Lymphoedema Education, Research & Treatment (ALERT) Program, Macquarie University, Sydney, Australia. louise.koelmeyer@mq.edu.au.ORCID http://orcid.org/0000-0002-2736-2330
Rachelle CrescenziDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1008-4570
Andrea ChevilleDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7668-6115

Funding

Visualizing vascular mechanisms of lipedemaR01HL157378 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CRESCENZI, RACHELLE L · 2021 to 2025
$2.5M
Imaging sodium and lymphatics in lymphedemaR01HL155523 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CRESCENZI, RACHELLE L · 2021 to 2025
$2.4M
NHLBI NIH HHS R01 HL155523NHLBI NIH HHS R01 HL157378
6 · The paper itself

Abstract

Lymphedema evaluation entails multifaceted considerations for which options continue to evolve and emerge. This paper provides a critical review of the current status of diagnostic and quantitative measures for lymphedema, from traditional and novel bedside assessment tools for volumetric and fluid assessment, to advanced imaging modalities. Modalities are contrasted with regard to empirical support and feasibility of clinical implementation. The manuscript proposes a grid framework for comparing the ability of each modality to quantify specific lymphedema characteristics, including distribution, dysmorphism, tissue composition and fluid content, lymphatic anatomy and function, metaplasia, clinical symptoms, and quality of life and function. This review additionally applies a similar framework approach to consider how well assessment tools support important clinical needs, including: (1) screening, (2) diagnosis and differential diagnosis, (3) individualization of treatment, and (4) monitoring treatment response. The framework highlights which clinical needs are served by an abundance of assessment tools and identifies others that have problematically few. The framework clarifies which tools have greater or lesser empirical support. The framework is designed to assist stakeholders in selecting appropriate diagnostic and surveillance modalities, gauging levels of confidence when applying tools to specific clinical needs, elucidating overarching patterns of diagnostic and quantitative strengths and weaknesses, and informing future investigation.

Indexed as

LymphedemaHumansQuality of LifeCancerDiagnosisImagingLymphedemaMeasurementMonitoringScreening

Identifiers

PMID39235664
PMCPMC11377676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.