Evidence map›Paper›PMID 39235659›Full record

ArticleApplied biochemistry and biotechnology2025

Biochemical Characterization of Hyaluronate Lyase CpHly8 from an Intestinal Microorganism Clostridium perfringens G1121.

Yongqing Fu, Zheng Fu, Jing Yu, Hainan Wang, Yuzhu Zhang, Mei Liu, Xiaolei Wang, Wengong Yu, Feng Han

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongqing Fu *School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Zheng Fu *School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Jing YuSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Hainan WangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Yuzhu ZhangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Mei LiuSchool of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Xiaolei WangSchool of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Wengong YuSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Feng HanSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. fhan@ouc.edu.cn.ORCID http://orcid.org/0000-0001-5706-7028

Funding

Natural Science Foundation of Shandong Province ZR2019ZD18Qingdao Marine Science and Technology Center 2022QNLM030003-1Science & Technology Development Project of Qingdao 20-11-6-64-gxScience & Technology Development Project of Qingdao 21-1-6-gjxm-27-gxScience & Technology Development Project of Qingdao 22-3-6-gjxm-5-gxShandong Province Technology Innovation Guidance Program 2018YFC0311105
6 · The paper itself

Abstract

Hyaluronic acid (HA) is an important component of extracellular matrices (ECM) and a linear polysaccharide involved in various physiological and pathological processes within the biological system. Several pathogens exploit HA degradation within the extracellular matrix to facilitate infection. While many intestinal microorganisms play significant roles in HA utilization in the human body, there remains a scarcity of related studies. This paper addressed this gap by screening intestinal microorganisms capable of degrading HA, resulting in the isolation of Clostridium perfringens G1121, which had been demonstrated the ability to degrade HA. Subsequent genome sequencing and analysis of C. perfringens G1121 revealed its utilization of the polysaccharide utilization loci of HA (PUL

Indexed as

Bacterial ProteinsClostridium perfringensHyaluronic AcidIntestinesPolysaccharide-LyasesAnimalsHydrogen-Ion ConcentrationMiceBacterial Proteinshyaluronate lyaseHyaluronic AcidPolysaccharide-LyasesClostridium perfringensHyaluronate lyaseIntestinal microorganismsSubcutaneous diffusion

Identifiers

PMID39235659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.