A Retrospective Tribute to Dr. Harish Pant (1938-2023) and His Seminal Work on Cyclin Dependent Kinase 5.

Bradford Hall, Niranjana Amin, Veeranna, Shin-Ichi Hisanaga, Ashok B Kulkarni

Abstract readBiographyHistorical Article

In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Bradford HallFunctional Genomics Section, National Institute of Dental and Craniofacial Research, Bethesda, MD, 20892, USA.

Niranjana AminCytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes and Health, Bethesda, MD, 20892, USA.

VeerannaCytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes and Health, Bethesda, MD, 20892, USA.

Shin-Ichi HisanagaLaboratory of Molecular Neuroscience, Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan.

Ashok B KulkarniFunctional Genomics Section, National Institute of Dental and Craniofacial Research, Bethesda, MD, 20892, USA. Ashok.Kulkarni@nih.gov.

Funding

Molecular Roles of Cdk5 in Neuronal Functions and Pain SignalingZIADE000664 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2009 to 2025

$20.4M

6 · The paper itself

Abstract

Dr. Harish Chandra Pant was Chief of the Section on Neuronal Cytoskeletal Protein Regulation within the National Institute of Neurological Disorders and Stroke at the NIH. A main focus of his group was understanding the mechanisms regulating neuronal cytoskeletal phosphorylation. Phosphorylation of neurofilaments can increase filament stability and confer resistance to proteolysis, but aberrant hyperphosphorylation of neurofilaments can be found in the neurofibrillary tangles that are seen with neurodegenerative diseases like Alzheimer disease (AD). Through his work, Harish would inevitably come across cyclin dependent kinase 5 (Cdk5), a key kinase that can phosphorylate neurofilaments at KSPXK motifs. Cdk5 differs from other Cdks in that its activity is mainly in post-mitotic neurons rather than being involved in the cell cycle in dividing cells. With continued interest in Cdk5, Harish and his group were instrumental in identifying important roles for this neuronal kinase in not only neuronal cytoskeleton phosphorylation but also in neuronal development, synaptogenesis, and neuronal survival. Here, we review the accomplishments of Harish in characterizing the functions of Cdk5 and its involvement in neuronal health and disease.

Indexed as

Cyclin-Dependent Kinase 5AnimalsHistory, 20th CenturyHistory, 21st CenturyHumansIndiaMarylandNational Institute of Neurological Disorders and Stroke (U.S.)NeuronsPhosphorylationCyclin-Dependent Kinase 5Alzheimer diseaseCyclin-dependent kinaseNeurofilamentNeuronsPain

Identifiers

PMID39235580

DOI10.1007/s11064-024-04234-5

PMCPMC11502590

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