ArticleScience China. Life sciences2024
Multi-omics analysis reveals the genetic and environmental factors in shaping the gut resistome of a keystone rodent species.
Article in Science China. Life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ecological and evolutionary drivers of trait-based symbiosis and phylosymbiosis in avian gut microbiota.Science China. Life sciences · 2026Article
- Comprehensive Sampling Across Seasons and Habitats Revealed the Composition and Functional Attributes of Gut Microbiota Enterotypes in Subterranean Rodents.Ecology and evolution · 2026Article
- Functional traits shape gut microbial assembly beyond phylogeny in estuarine fish.Science China. Life sciences · 2026Article
- Prenatal exposure to predator odor alters placental glucocorticoid metabolism and affects fetal growth in Brandt's voles (Current zoology · 2026Article
- Diet and environmental factors jointly drive the gut microbiome, resistome, and virulome of urban bats.NPJ biofilms and microbiomes · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Uncovering the gut microbiome and antibiotic resistome of mammals on the Tibetan Plateau.Science China. Life sciences · 2025Article
- EMitool: Explainable Multi-Omics Integration for Disease Subtyping.International journal of molecular sciences · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Understanding the emergence and spread of antibiotic resistance genes (ARGs) in wildlife is critical for the health of humans and animals from a "One Health" perspective. The gut microbiota serve as a reservoir for ARGs; however, it remains poorly understood how environmental and host genetic factors influence ARGs by affecting the gut microbiota. To elucidate this, we analyzed whole-genome resequencing data from 79 individuals of Brandt's vole in two geographic locations with different antibiotics usage, together with metabolomic data and shotgun sequencing data. A high diversity of ARGs (851 subtypes) was observed in vole's gut, with a large variation in ARG composition between individuals from Xilingol and Hulunbuir in China. The diversity and composition of ARGs were strongly correlated with variations in gut microbiota community structure. Genome-wide association studies revealed that 803 loci were significantly associated (P<5.05×10
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