Evidence map›Paper›PMID 39235510›Full record

ArticleCancer immunology, immunotherapy : CII2024

Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma.

Sarah M Zimmerman, Erin Suh, Sofia R Smith, George P Souroullas

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sarah M ZimmermanDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.
Erin SuhUniversity of Georgia, Athens, GA, USA.
Sofia R SmithDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.
George P SouroullasDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA. george.souroullas@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
NCI NIH HHS P30 CA091842NCI NIH HHS T32 CA113275NIH HHS T32 CA113275-10
6 · The paper itself

Abstract

Epigenetic modifications to DNA and chromatin control oncogenic and tumor-suppressive mechanisms in melanoma. Ezh2, the catalytic component of the Polycomb Repressive Complex 2 (PRC2), which mediates methylation of lysine 27 on histone 3 (H3K27me3), can regulate both melanoma initiation and progression. We previously found that mutant Ezh2

Indexed as

Autophagy-Related Protein 7Enhancer of Zeste Homolog 2 ProteinSTAT3 Transcription FactorAnimalsAutophagyCD8-Positive T-LymphocytesCell Line, TumorEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMelanomaMelanoma, ExperimentalMiceMice, Inbred C57BLTumor MicroenvironmentAtg7 protein, mouseAutophagy-Related Protein 7Enhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorAtg7AutophagyMelanomaTumor-immune response

Identifiers

PMID39235510
PMCPMC11377374

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.