Evidence map›Paper›PMID 39235500›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Association of contrast sensitivity with vessel density and functional parameters in different stages of glaucoma.

I-Wen Lai, Tsing-Hong Wang, Jehn-Yu Huang, Chien-Chia Su

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

I-Wen LaiDepartment of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan S. Rd, Taipei, Taiwan.
Tsing-Hong WangDepartment of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan S. Rd, Taipei, Taiwan.
Jehn-Yu HuangDepartment of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan S. Rd, Taipei, Taiwan.
Chien-Chia SuDepartment of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan S. Rd, Taipei, Taiwan. chienchiasu@ntu.edu.tw.ORCID http://orcid.org/0000-0002-9220-7599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the association between contrast sensitivity (CS), vessel density (VD), and functional parameters in patients with glaucoma of varying severity.

methodsNinety-four eyes of 94 patients (57 men and 37 women, aged 56.52 ± 11.28 years) were divided into mild and moderate to advanced glaucoma groups. The mild glaucoma group was further subdivided based on the presence of central visual field defect (CVFD). Pearson's correlations were used to evaluate the associations between area under the log CS function (AULCSF), best-corrected visual acuity (BCVA), 10 - 2 visual field (VF), and structural parameters, including VD. The area under the receiver operating characteristic (AUROC) curve was calculated to detect abnormal CS (AULCSF < 1.2).

resultsIn mild glaucoma without CVFD, AULCSF was associated with radial peripapillary capillary VD (γ = 0.597, P = 0.001), with an AUROC of 0.840 (P = 0.006) for detecting abnormal CS. In mild glaucoma with CVFD, AULCSF worsened and was associated with superficial parafoveal VD (γ = 0.569, P = 0.017) and macular whole image VD (γ = 0.632, P = 0.007), with AUROCs of 0.833 (P = 0.021) and 0.792 (P = 0.043), respectively. In moderate to advanced glaucoma, the relationship between AULCSF and the mean deviation of 10 - 2 VF and BCVA was more robust than that observed in structural measures.

conclusionsDecreased VD is linked to early CS impairment. Radial peripapillary capillary and macular VD can serve as indicators of CS function in the early stages of glaucoma. KEY  MESSAGES: What is known Contrast sensitivity loss has been reported in glaucoma patients but its relationship with glaucoma-related structural and functional changes in different glaucoma severity and central visual field defect (CVFD) remains elusive. What is new Decline in RPC peripapillary vessel density was associated with early impairment of contrast sensitivity in mild glaucoma without CVFD. Decline in macular vessel density and central 16 points of 10-2 visual field damage were associated with contrast sensitivity reduction in mild glaucoma with CVFD. Microvasculature change can serve as an indicator for abnormal contrast sensitivity.

Indexed as

Contrast SensitivityGlaucomaGlaucoma, Open-AngleIntraocular PressureOptic DiskRetinal Ganglion CellsRetinal VesselsTomography, Optical CoherenceVisual AcuityVisual FieldsAgedFemaleFluorescein AngiographyFollow-Up StudiesHumansMaleCentral visual field defectContrast sensitivityGlaucomaVessel density

Identifiers

PMID39235500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.