Evidence map›Paper›PMID 39235463›Full record

ArticleEuropean child & adolescent psychiatry2025

Periaqueductal gray subregions connectivity and its association with micturition desire-awakening function.

Shaogen Zhong, Xindi Lin, Mengxing Wang, Yi Mao, Jiayao Shen, Xiaoxia Du, Lichi Zhang, Jun Ma

Abstract read
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In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaogen Zhong *Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Rd. Pudong District, Shanghai, 200127, China.
Xindi Lin *Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Rd. Pudong District, Shanghai, 200127, China.
Mengxing WangCollege of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Yi MaoDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Rd. Pudong District, Shanghai, 200127, China.
Jiayao ShenDepartment of Nephrology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaoxia DuDepartment of Psychology, Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China.
Lichi ZhangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. lichizhang@sjtu.edu.cn.
Jun MaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Rd. Pudong District, Shanghai, 200127, China. majun@shsmu.edu.cn.

Funding

Medical Innovation Research Project of Shanghai 22Y11920100National Natural Science Foundation of China 62001292National Natural Science Foundation of China 81901720Natural Science Foundation of Shanghai 20ZR1434700
6 · The paper itself

Abstract

Existing literature strongly supports the idea that children with primary nocturnal enuresis (PNE) have brainstem abnormalities. However, the connection between pre-micturition arousal responses and brain functional connectivities is still not clearly defined. Our study investigated the correlation between the gradations of micturition desire-awakening (MDA) functionality and the functional connectivity of the midbrain periaqueductal gray (PAG), a pivotal brainstem hub implicated in the neural regulation of micturition in humans. Neuroimaging and behavioral data from 133 patients with PNE and 40 healthy children were acquired from functional magnetic resonance imaging (fMRI) and precise clinical observations, respectively. The whole-brain correlation analyses were undertaken to elucidate the complex connectivity patterns between the subregions of PAG and the cerebral cortex, with a focus on their correlation to the spectrum of MDA functionality. A positive correlation was identified between MDA dysfunction and the resting-state functional connectivity (RSFC) between the left ventrolateral periaqueductal gray (vlPAG) and the right temporal pole of the superior temporal gyrus. Conversely, a negative correlation was observed between MDA dysfunction and the RSFC of the right vlPAG with the right superior parietal lobule. Additionally, MDA dysfunction exhibited a negative association with the RSFC between the dorsomedial PAG (dmPAG) and the right inferior parietal lobule. These findings may indicate that the specific signal from a distended bladder is blocked in the PAG and its functional connectivity with the executive function, attention, and default mode networks, ultimately leading to impaired arousal and bladder control. This revelation underscores potential neural targets for future therapeutic interventions.

Indexed as

Cerebral CortexNocturnal EnuresisPeriaqueductal GrayUrinationAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysChildrenFunctional connectivityMicturition desire-awakening functionPeriaqueductal grayPrimary nocturnal enuresisResting-state fMRI

Identifiers

PMID39235463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.