Evidence map›Paper›PMID 39235234›Full record

ArticleJournal of bacteriology2024

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in

Yutian Peng, John G Moffat, Cory DuPai, Eric M Kofoed, Elizabeth Skippington, Zora Modrusan, Susan L Gloor, Kevin Clark, Yiming Xu, Shuxuan Li and 10 more

Abstract read
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yutian PengDepartment of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.ORCID 0000-0002-8663-7330
John G MoffatDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.
Cory DuPaiDepartment of Bioinformatics, Genentech Inc., South San Francisco, California, USA.
Eric M KofoedDepartment of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.
Elizabeth SkippingtonDepartment of Bioinformatics, Genentech Inc., South San Francisco, California, USA.
Zora ModrusanDepartment of Proteomic and Genomic Technologies, Genentech Inc., South San Francisco, California, USA.
Susan L GloorDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.
Kevin ClarkDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.
Yiming XuDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.
Shuxuan LiDepartment of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.
Liuxi ChenDepartment of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.
Xingrong LiuDepartment of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.
Ping WuDepartment of Structural Biology, Genentech Inc., South San Francisco, California, USA.
Seth F HarrisDepartment of Structural Biology, Genentech Inc., South San Francisco, California, USA.
Shumei WangDepartment of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA.
Terry D CrawfordDepartment of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA.
Chun Sing LiWuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.
Zhiguo LiuWuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.
John WaiWuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.
Man-Wah TanDepartment of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.ORCID 0000-0002-7748-212X

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P30 GM124169-01NIGMS NIH HHS P30 GM124169
6 · The paper itself

Abstract

Inosine 5'-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step in

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsEnzyme InhibitorsEscherichia coliIMP DehydrogenaseBacterial ProteinsGene Expression Regulation, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsIMP DehydrogenaseAcinetobacter baumanniiantibacterialde novo guanine biosynthesisEscherichia coliGuaBinosine monophosphate dehydrogenase

Identifiers

PMID39235234
PMCPMC11500612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.