Evidence map›Paper›PMID 39234984›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Refined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke.

Matej Skrobot, Rafael De Sa, Josefine Walter, Arend Vogt, Raik Paulat, Janet Lips, Larissa Mosch, Susanne Mueller, Sina Dominiak, Robert Sachdev and 5 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Toward development of a dynamic supramolecular peptide therapy for acute ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. A stuttering-associatedbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matej SkrobotDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-6686-1880
Rafael De SaDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Josefine WalterDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Arend VogtDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-0925-0308
Raik PaulatDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Janet LipsDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Larissa MoschDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Susanne MuellerDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-8777-4823
Sina DominiakInstitute of Biology, Humboldt University of Berlin, Berlin, Germany.
Robert SachdevSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
Philipp Boehm-SturmDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ulrich DirnaglDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Matthias EndresDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christoph HarmsDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-2063-2860
Nikolaus WengerDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate assessment of post-stroke deficits is crucial in translational research. Recent advances in machine learning offer precise quantification of rodent motor behavior post-stroke, yet detecting lesion-specific upper extremity deficits remains unclear. Employing proximal middle cerebral artery occlusion (MCAO) and cortical photothrombosis (PT) in mice, we assessed post-stroke impairments via the Staircase test. Lesion locations were identified using 7 T-MRI. Machine learning was applied to reconstruct forepaw kinematic trajectories and feature analysis was achieved with

Indexed as

Disease Models, AnimalInfarction, Middle Cerebral ArteryStrokeAnimalsMachine LearningMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMovementMachine learningmotor deficitsrodent modelsstroketranslational research

Identifiers

PMID39234984
PMCPMC11418716

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.