Evidence map›Paper›PMID 39234903›Full record

SynthesisInfectious disorders drug targets2025

Biological Mechanisms of Polyphenols against

Mohammad Darvishi, Seyed Mahmoud Reza Hashemi Rafsanjani, Majid Nouri, Saber Abbaszadeh, Saeid Heidari-Soureshjani, Karamali Kasiri, Ghorbanali Rahimian

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Infectious disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad DarvishiInfectious Diseases and Tropical Medicine Research Center (IDTMRC), School of Aerospace and Subaquatic Medicine, Aja University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-0332-2489
Seyed Mahmoud Reza Hashemi RafsanjaniFaculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.ORCID 0009-0003-2379-9628
Majid NouriInfectious Diseases and Tropical Medicine Research Center (IDTMRC), Aja University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-4110-7141
Saber AbbaszadehDepartment of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.ORCID 0000-0002-2280-2499
Saeid Heidari-SoureshjaniModeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.ORCID 0000-0002-7592-3868
Karamali KasiriDepartment of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.ORCID 0000-0002-3014-051X
Ghorbanali RahimianDepartment of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.ORCID 0000-0001-8080-6116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClostridium difficile is an opportunistic infection that can lead to antibiotic- associated diarrhea and toxic megacolon.

objectiveThis systematic review study aimed to investigate polyphenols' antibacterial and antitoxin properties and their effects on reducing complications related to C. difficile Infections (CDI).

methodsThis systematic review was conducted following the PRISMA guideline 2020. Multiple databases, including Web of Science, PubMed, Cochrane Library, EMBASE, and Scopus, were searched thoroughly for existing literature. After considering the inclusion and exclusion criteria for the review, 18 articles were included. Data were collected and registered into an Excel file for further investigations and conclusions.

resultsPolyphenols by reducing Reactive Oxygen Species (ROS) levels, increasing inflammatory factor Interleukin 10 (IL-10), reducing Nuclear Factor kappa B (NF-κB) and Tumour Necrosis Factor- α (TNF-α), IL-6, IL-1α, IL-1β, Granulocyte Colony-stimulating Factor (G-CSF), and Monocyte Chemoattractant Protein-1 (MCP-1) and Macrophage Inflammatory Protein-1 alpha (MIP-1α) levels, and regulating the expression of Bcl-2 and Bax, make the growth and replication conditions of

conclusionPolyphenols have been reported to inhibit C. difficile growth and toxin production by several mechanisms in preclinical studies. However, more clinical studies are needed to investigate their safety in humans.

Indexed as

Anti-Bacterial AgentsClostridioides difficileClostridium InfectionsPolyphenolsAnimalsHumansReactive Oxygen SpeciesAnti-Bacterial AgentsPolyphenolsReactive Oxygen SpeciesClostridioides difficileClostridium difficilediarrheapolyphenolreactive oxygen species.systematic reviewtoxic megacolon

Identifiers

PMID39234903

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.