Evidence map›Paper›PMID 39234873›Full record

ArticleHaematologica2025

Blinatumomab is associated with better post-transplant outcome than chemotherapy in children with high-risk, first-relapse B-cell acute lymphoblastic leukemia irrespective of the conditioning regimen.

Christina Peters, Angela Bruno, Carmelo Rizzari, Alessandra Brescianini, Arend Von Stackelberg, Christin Linderkamp, Yi Zeng, Gerhard Zugmaier, Franco Locatelli

Registry-linked trialAbstract read
In one paragraph

Article in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02393859 (Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as Consolidation Therapy Versus Conventional Consolidation Chemotherapy in Pediatric Subjects With HR First Relapse B-precursor ALL), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02393859 phase3completednot on this map

Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as Consolidation Therapy Versus Conventional Consolidation Chemotherapy in Pediatric Subjects With HR First Relapse B-precursor ALL

TypeinterventionalSponsorAmgenRan2015 to 2022Enrolled111ConditionsLeukemia, Acute LymphoblasticArmsBlinatumomab, Dexamethasone, Vincrisitne, Daunorubicin, Methotrexate
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. [Recent advances in individualized treatment for pediatric high-risk B-cell acute lymphoblastic leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  2. Review
  3. Peri-transplant conundrums: optimizing maintenance therapy using MRD-directed approaches.Hematology. American Society of Hematology. Education Program · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina PetersSt. Anna Children's Hospital, St. Anna Children's Cancer Research Institute, University Vienna, Vienna.
Angela BrunoAmgen Italia, Milan.
Carmelo RizzariMBBM Foundation, University of Milano-Bicocca, Monza.
Alessandra BrescianiniAmgen (Europe) GmbH, Rotkreuz.
Arend Von StackelbergCharité Universitaetsmedizin CVK Berlin, Berlin.
Christin LinderkampMedizinische Hochschule Hannover, Hannover.
Yi ZengAmgen Inc., Thousand Oaks, CA.
Gerhard ZugmaierAmgen Research (Munich) GmbH, Munich. gerhardz@amgen.com.
Franco LocatelliIRCCS Ospedale Pediatrico Bambino Gesù and Catholic University of the Sacred Heart, Rome.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39234873
PMCPMC11694122

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.