Evidence map›Paper›PMID 39234865›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure.

Farren Bs Briggs, Douglas D Gunzler, Deborah M Miller, Daniel Ontaneda, Alessandro S De Nadai

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. NMOSD and MOGAD: an evolving disease spectrum.Nature reviews. Neurology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Farren Bs BriggsDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-0903-1359
Douglas D GunzlerDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Deborah M MillerThe Mellen Center for Multiple Sclerosis and Research, Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID 0000-0002-8026-1854
Daniel OntanedaThe Mellen Center for Multiple Sclerosis and Research, Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID 0000-0002-2838-9148
Alessandro S De NadaiMcLean Hospital, Harvard Medical School, Belmont, MA, USA.

Funding

Elucidating symptoms clusters in multiple sclerosis using patient reported outcomes and unsupervised machine learningR56NR019306 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI BRIGGS, FARREN B. S., DE NADAI, ALESSANDRO STEVENS · 2021 to 2022
$297k
NINR NIH HHS R56 NR019306
6 · The paper itself

Abstract

backgroundLoss of mobility is common in persons with multiple sclerosis (PwMS), but little is known about this impairment from the patient's perspective.

objectiveThe aim is to model longitudinal variation in a mobility patient-reported outcome (PRO) and compare trajectories to those observed for Timed 25-Foot Walk (T25FW) in a retrospective cohort.

methodsLatent-class growth analysis was applied to 47,508 measures of Performance Scales© Mobility PRO (PS-Mobility) over ~4 years for 8524 PwMS. For 7347 PwMS, there were 41,988 T25FW measures during this period. Repeated measures correlation and concordance of trajectory assignment were evaluated.

resultsAt the group level, PS-Mobility and T25FW linearly worsened and repeated-measures correlation was moderate. Eight latent classes with varying shapes that worsened described PS-Mobility variation, compared to six latent classes for T25FW that differed by intercept. The agreement between PS-Mobility and T25FW cluster assignment was modest. A higher proportion of individuals who were Black/African American, older, Medicaid beneficiaries, living in deprived neighborhoods, had longer disease duration, had progressive disease, and ever smokers were assigned to more impaired clusters. DISCUSSION: Cross-sectionally, PS-Mobility and T25FW were highly correlated, but longitudinally correlation was modest to moderate, underscoring the importance of considering both objective and subjective perspectives in evaluating mobility changes in PwMS.

Indexed as

Mobility LimitationMultiple SclerosisPatient Reported Outcome MeasuresWalkingAdultAgedDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedRetrospective Studiesambulatory impairmentlatent-class growth analysismobilityMultiple sclerosispatient-reported outcometimed 25-foot walk

Identifiers

PMID39234865
PMCPMC11502245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.