ArticleProceedings of the National Academy of Sciences of the United States of America1985
Perpetual production of hair cells and maturational changes in hair cell ultrastructure accompany postembryonic growth in an amphibian ear.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 182 citations in OpenAlex.
- On the value of diverse organisms in auditory research: From fish to flies to humans.Hearing research · 2023Review
- Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Frontiers in cell and developmental biology · 2022Article
- Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors.Frontiers in cell and developmental biology · 2021Article
- Tadpole bioacoustics: Sound processing across metamorphosis.Behavioral neuroscience · 2019Review
- Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.Development (Cambridge, England) · 2019Review
- Article
- Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a.eLife · 2017Article
- Comparative and developmental patterns of amphibious auditory function in salamanders.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Profiles of the auditory epithelia related microRNA expression in neonatal and adult rats.European journal of medical research · 2014Article
- A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".Hearing research · 2013Review
- Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio).PloS one · 2013Article
- Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zones.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- In vivo proliferative regeneration of balance hair cells in newborn mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Stem cell therapy for the inner ear: recent advances and future directions.Trends in amplification · 2012Review
- Concise review: Inner ear stem cells--an oxymoron, but why?Stem cells (Dayton, Ohio) · 2012Review
- Review
- Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus.PloS one · 2010Article
- The challenge of hair cell regeneration.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Feathers and fins: non-mammalian models for hair cell regeneration.Brain research · 2009Review
- Stem/progenitor cells derived from the cochlear sensory epithelium give rise to spheres with distinct morphologies and features.Journal of the Association for Research in Otolaryngology : JARO · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory hair cells are produced in the ears of birds and mammals only during early development, so that a programmed termination of hair cell proliferation leaves adult birds and mammals susceptible to irreversible deafness and balance disorders. This study reports that this is not an inherent feature of hair cells and is not shared through all the vertebrate classes. In toads (Bufo marinus) hair cells accumulate throughout life, increasing in the sacculus from approximately 400 cells at metamorphosis to more than 1600 in adulthood. In both embryonic and postembryonic ears new hair cells have been identified by scanning electron microscopy and through uptake of radioactively labeled thymidine. In the otic vesicle of postneurulation embryos there is a single primordial sensory epithelium that contains approximately 100 hair cells. Scanning electron microscopy has demonstrated that these newly formed hair cells all have stereocilia bundles that are shorter than 1.5 micron, whereas the majority of hair cells in postembryonic ears have stereocilia bundles that are at least 3 micron long. In the postembryonic sacculus the proliferation of hair cells never appears to cease, since newly produced hair cells identified by their short stereocilia have been found in a distinct peripheral growth zone at the edge of the sensory epithelium even in specimens from the oldest 1% of natural populations. This peripheral growth zone is also the site of the most frequent labeling of newly synthesized DNA in hair cells. It appears that the postembryonic enlargement of the toad sacculus occurs primarily through appositional addition of new hair cells at its edge, with few hair cells added within the existing structure of the epithelium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.