ArticleCurrent neuropharmacology2024
Glymphatic System and Psychiatric Disorders: A Rapid Comprehensive Scoping Review.
Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychiatric disorders in the course to SARS-CoV-2 virus infection, including biological pathomechanisms, psychosocial factors and long COVID-19 associated with "brain fog".Journal of neurovirology · 2025Pooled it
- Increased Activity of the Glymphatic System in First-Episode Psychosis: Relationship With Cortical Thinning.JAACAP open · 2026Article
- Modulation of depression through the neurobiological underpinnings of the glymphatic-rumination relationship.Psychological medicine · 2026Article
- Physical exercise as a non-pharmacological strategy to enhance glymphatic function.IBRO neuroscience reports · 2026Review
- Article
- Co-exposure to lead and cadmium is associated with increased severity of social deficits in children with autism spectrum disorders.Frontiers in nutrition · 2026Article
- Review
- Correlation analysis of psychiatric and behavioral symptoms with cognitive impairment and prognosis in patients with general paresis.Frontiers in psychiatry · 2026Article
- Association Between Glymphatic Dysfunction and Anxiety in Parkinson's Disease: Insights from DTI-ALPS and Choroid Plexus Volume.Neuropsychiatric disease and treatment · 2026Article
- Prevalence and risk factors of postpartum depression, anxiety, and comorbidity of both disorders: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Glymphatic System Dysregulation as a Key Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.International journal of molecular sciences · 2025Review
- Re-Examination of Inflammation in Major Depressive Disorder: Bridging Systemic and Neuroinflammatory Insights.Biomolecules · 2025Review
- Association of hepatorenal function biomarkers with depression risk in geriatric psychiatry inpatient: a hospital-based cross-sectional study.BMC geriatrics · 2025Article
- Blue light treatment of psychiatric disorders: relationships with systemic inflammation, lipid metabolism, and clinical symptoms.BMC psychiatry · 2025Article
- Prediction model for depression risk in middle-aged and elderly patients with metabolic syndrome: a nomogram and interpretable machine learning approach based on CHARLS.BMC psychiatry · 2025Article
- Associations of depression, anxiety, and insomnia symptoms in subthreshold depression: a network analysis.BMC psychiatry · 2025Article
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Glymphatic system dysfunction correlated with gut dysbiosis and cognitive impairment in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Cerebral Small Vessel Disease Outperforms Brain Atrophy as an Imaging Biomarker in Diabetic Retinopathy.Journal of diabetes · 2025Article
- Glymphatic system and psychiatric disorders: need for a new paradigm?Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince discovering the glymphatic system, there has been a looming interest in exploring its relationship with psychiatric disorders. Recently, increasing evidence suggests an involvement of the glymphatic system in the pathophysiology of psychiatric disorders. However, clear data are still lacking. In this context, this rapid comprehensive PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) scoping review aims to identify and analyze current evidence about the relation between the glymphatic system and psychiatric disorders.
methodsWe conducted a comprehensive review of the literature and then proceeded to discuss the findings narratively. Tables were then constructed and articles were sorted according to authors, year, title, location of study, sample size, psychiatric disorder, the aim of the study, principal findings, implications.
resultsTwenty papers were identified as eligible, among which 2 articles on Schizophrenia, 1 on Autism Spectrum Disorders, 2 on Depression, 1 on Depression and Trauma-related Disorders, 1 on Depression and Anxiety, 2 on Anxiety and Sleep Disorders, 8 on Sleep Disorders, 2 on Alcohol use disorder and 1 on Cocaine Use Disorder.
conclusionThis review suggests a correlation between the glymphatic system and several psychiatric disorders: Schizophrenia, Depression, Anxiety Disorders, Sleep Disorders, Alcohol Use Disorder, Cocaine Use Disorder, Trauma-Related Disorders, and Autism Spectrum Disorders. Impairment of the glymphatic system could play a role in Trauma-Related Disorders, Alcohol Use Disorders, Cocaine Use Disorders, Sleep Disorders, Depression, and Autism Spectrum Disorders. It is important to implement research on this topic and adopt standardized markers and radio diagnostic tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.