ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How loneliness and social isolation are linked to cognitive decline among older adults? A systematic review of underlying physiological and psychobehavioral mechanisms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Loneliness as an Interface Between Alzheimer's Disease and Suicidal Behaviour: A Systematic Review, Meta-Analysis and Meta-Analytic Factor Analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Pooled it
- Chronic hypertension and social isolation disrupt the blood-brain barrier and memory in a sex-dependent manner.Neurobiology of disease · 2026Article
- Loneliness and Plasma Biomarkers of Neurodegeneration in Community-Dwelling Older Adults: Cross-Sectional and Longitudinal Analyses.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Risk Factors for Anxiety or Depression in Patients With Stroke During the Acute and Recovery Phases: An Independent Cohort Study.Actas espanolas de psiquiatria · 2026Article
- Loneliness as a sex-specific risk factor for cognitive aging.Frontiers in human neuroscience · 2026Review
- Cerebrovascular disease in Alzheimer's disease: Brain structure as a critical mediator of cognitive decline.The journal of prevention of Alzheimer's disease · 2025Article
- Article
- A University's Role in Developing a Regional Network of Dementia Friendly Communities.International journal of environmental research and public health · 2025Article
- Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Loneliness trajectories and dementia risk: Insights from the HUNT cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Social interaction mitigates cognitive impairments and tau pathology in socially isolated aged mice.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
introductionLoneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited.
methodsInverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression.
resultsIn weighted models, greater loneliness was associated with microinfarcts, lower episodic and working memory in the absence of AD pathology, lower working memory in the absence of infarcts, a stronger association of infarcts with lower episodic memory, and a stronger association of microinfarcts with lower working and semantic memory. DISCUSSION: Loneliness may relate to AD through multiple pathways involving cerebrovascular pathology and cognitive reserve. HIGHLIGHTS: Loneliness was associated with worse cognition in five domains. Loneliness was associated with the presence of microinfarcts. Loneliness moderated cognition-neuropathology associations. Transportability methods can provide insight into selection bias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.