ArticleFrontiers in endocrinology2024
Neutrophil-to-lymphocyte ratio as a predictor of all-cause and cardiovascular mortality in coronary heart disease and hypertensive patients: a retrospective cohort study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Advanced lung cancer inflammation index and mortality risk in patients with cardiovascular disease.BMC cardiovascular disorders · 2026Article
- Association of the novel remnant cholesterol inflammatory index with acute coronary syndrome risk in hospitalized patients with diabetes: a two-center study.Scientific reports · 2026Article
- Cross-sectional associations and incremental discrimination of inflammatory and lipid-derived indices for prevalent coronary heart disease in type 2 diabetes.Frontiers in endocrinology · 2026Article
- Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data.Frontiers in immunology · 2026Article
- Neutrophil-to-lymphocyte ratio as a predictor of post-ablation recurrence in hypertensive patients with paroxysmal atrial fibrillation.International journal of medical sciences · 2026Article
- Systemic inflammation modulates lipoprotein(a)-associated coronary stenosis in the chronic coronary syndromes.American journal of preventive cardiology · 2025Article
- Neutrophil-to-Lymphocyte Ratio as Potential Marker of Outcome After Standard EVAR.Diagnostics (Basel, Switzerland) · 2025Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
- Observational
- Neutrophil-to-Lymphocyte Ratio, Bone Marrow, and Visceral Fat Metabolism as Predictors of Future Cardiovascular Disease in an Asymptomatic Healthy Population.Journal of clinical medicine · 2025Article
- The relationship between pan-immune inflammation value and different stages of diabetic retinopathy in patients with type 2 diabetes mellitus: a prospective cross-sectional study.BMC endocrine disorders · 2025Article
- Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients.Cardiovascular diabetology · 2025Article
- Association between dietary index for gut microbiota and metabolic syndrome risk: a cross-sectional analysis of NHANES 2007-2018.Scientific reports · 2025Article
- Prognostic value of the neutrophil to lymphocyte ratio for cardiovascular diseases: research progress.American journal of translational research · 2025Review
- Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018.Frontiers in endocrinology · 2025Article
- Comprehensive Analysis of the Correlation Between Immune-Inflammatory Biomarkers and Intestinal Necrosis in Patients With Acute Intestinal Ischemia.Mediators of inflammation · 2025Article
- The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease.Journal of inflammation research · 2025Article
- Impact of the Naples Prognostic Score at admission on long-term prognosis among patients with coronary artery disease.Frontiers in immunology · 2025Article
- Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2025Article
- Association of the neutrophil-to-lymphocyte ratio with sudden cardiac death in the patients with diabetic foot ulcer.Frontiers in endocrinology · 2025Article
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Abstract
Background: To date, no studies have investigated the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the long-term risk of mortality in individuals with both coronary heart disease (CHD) and hypertension. This study aims to evaluate the association between NLR and all-cause and cardiovascular mortality among this patient population. Methods: National Death Index (NDI) and National Health and Nutrition Examination Survey (NHANES 2001-2018) were the data sources. A nonlinear association between the NLR and mortality risk was shown by restricted cubic spline (RCS) analysis. Using a weighted Cox proportional hazards model, we quantitatively evaluated the effect of NLR on mortality risk.The capacity of NLR to forecast survival was assessed by evaluating time-dependent receiver operating characteristic (ROC) curves. A mediating influence analysis was conducted to assess the influence of NLR on mortality through eGFR as a mediator. Results: The study involved a total of 2136 individuals. During the median follow-up interval of 76.0 months, 801 deaths were recorded. The RCS analysis showed NLR and mortality risk to have a nonlinear relationship. Two groups were established based on the participants' NLR levels: a group with high NLR (NLR > 2.65) and a group with low NLR (NLR < 2.65). After adjusting for potential confounding factors, the Cox proportional hazards model revealed that participants with an increased NLR faced a significantly higher risk of cardiovascular mortality. (HR 1.58, 95% CI 1.33-1.82, Conclusion: For patients with CHD and hypertension, an elevated NLR serves as an independent prognostic indicator for both all-cause and cardiovascular mortality.
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