Evidence map›Paper›PMID 39234505›Full record

ArticleFrontiers in endocrinology2024

The metabolomics changes in epididymal lumen fluid of CABS1 deficient male mice potentially contribute to sperm deformity.

Xiuling Zhao, Junyu Nie, Wenwen Zhou, Xuhui Zeng, Xiaoli Sun

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Metabolomic Analysis of Cauda Epididymal Fluid in Yaks and Cattle.Animals : an open access journal from MDPI · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiuling Zhao *Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, Jiangsu, China.
Junyu Nie *Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, Jiangsu, China.
Wenwen ZhouInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong, Jiangsu, China.
Xuhui ZengInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong, Jiangsu, China.
Xiaoli SunCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Epididymal lumen fluids provides a stable microenvironment for sperm maturation. Ca Methods: To further confirm the role of CABS1 in epididymis, we identified the expression of CABS1 in epididymal lumen fluids. Moreover, high performance liquid chromatography, coupled with tandem mass spectrometry technique was used to analyze the metabolic profiles and Results: The results showed that CABS1 is present in epididymal lumen fluids, and the concentration of calcium in epididymal lumen fluids is not changed in Discussion: The perturbations of mitochondrial dysfunction and inflammation may be the crucial reason for the poor performance of

Indexed as

EpididymisMetabolomicsMice, KnockoutSpermatozoaAnimalsCalcium-Binding ProteinsMaleMiceMice, Inbred C57BLSperm MaturationCABS1 protein, mouseCalcium-Binding ProteinsCABS1epididymal lumen fluidLC-MSmetabolomicssperm maturation

Identifiers

PMID39234505
PMCPMC11371703

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.