Evidence map›Paper›PMID 39234407›Full record

ArticleFrontiers in human neuroscience2024

Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease.

Anantajit Subrahmanya, Kamalini G Ranasinghe, Hardik Kothare, Inez Raharjo, Kwang S Kim, John F Houde, Srikantan S Nagarajan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anantajit SubrahmanyaDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Kamalini G RanasingheDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United States.
Hardik KothareDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Inez RaharjoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Kwang S KimDepartment of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, United States.
John F HoudeDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.

Funding

The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Electrophysiological and molecular imaging of early AD progressionR01AG088398 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kamalini Gayathree Ranasinghe · 2024 to 2026
$2.4M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaRF1NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA, HOUDE, JOHN FRANCIS · 2023 to 2023
$2.4M
Neurophysiological Assessments of Network Dysfunction in Alzheimer's DiseaseK08AG058749 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2019 to 2023
$859k
Multimodal imaging measures to assess synaptic dysfunction in Alzheimer's diseaseR21AG077498 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2022 to 2022
$484k
NIA NIH HHS K08 AG058749NIA NIH HHS R01 AG088398NIA NIH HHS R21 AG077498NIDCD NIH HHS R01 DC017091NINDS NIH HHS R01 NS100440NINDS NIH HHS RF1 NS100440
6 · The paper itself

Abstract

Past studies have explored formant centering, a corrective behavior of convergence over the duration of an utterance toward the formants of a putative target vowel. In this study, we establish the existence of a similar centering phenomenon for pitch in healthy elderly controls and examine how such corrective behavior is altered in Alzheimer's Disease (AD). We found the pitch centering response in healthy elderly was similar when correcting pitch errors below and above the target (median) pitch. In contrast, patients with AD showed an asymmetry with a larger correction for the pitch errors below the target phonation than above the target phonation. These findings indicate that pitch centering is a robust compensation behavior in human speech. Our findings also explore the potential impacts on pitch centering from neurodegenerative processes impacting speech in AD.

Indexed as

Alzheimer's diseaseauditory feedbackspeech controlspeech perceptionspeech production

Identifiers

PMID39234407
PMCPMC11371567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.