Evidence map›Paper›PMID 39234310›Full record

ArticleFrontiers in physiology2024

Impact of a tailored exercise regimen on physical capacity and plasma proteome profile in post-COVID-19 condition.

Mohammad Mobarak H Chowdhury, Marie-Noelle Fontaine, Sarah-Eve Lord, Akouavi Julite Irmine Quenum, Marc-André Limoges, Christine Rioux-Perreault, Jean-François Lucier, Dominic O Cliche, Dominique Levesque, François-Michel Boisvert and 7 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mohammad Mobarak H Chowdhury *Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Marie-Noelle Fontaine *Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Sarah-Eve Lord *Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Akouavi Julite Irmine QuenumDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Marc-André LimogesDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Christine Rioux-PerreaultDepartment of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Jean-François LucierDepartment of Biology, Faculty of Science, Université de Sherbrooke, Sherbrooke, QC, Canada.
Dominic O ClicheDepartment of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Dominique LevesqueResearch Centre on Aging, Affiliated with CIUSSS de L'Estrie-CHUS, Sherbrooke, QC, Canada.
François-Michel BoisvertDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
André M CantinDepartment of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Hugues Allard-ChamardDepartment of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Alfredo MenendezDepartment of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Subburaj IlangumaranDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Alain Piché *Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Isabelle J Dionne *Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Sheela Ramanathan *Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Individuals affected by the post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicates the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC were assigned sequentially to exercise ( Results: Bicep Curl (+15% vs 4%; Conclusions: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.

Indexed as

exercisefatiguelong COVIDoxidative stressphysical activityphysical capacitypost COVID-19 conditionsymptoms

Identifiers

PMID39234310
PMCPMC11371593

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.